Title:
LSP1-DEFICIENT T CELL
Document Type and Number:
WIPO Patent Application WO/2021/242002
Kind Code:
A1
Abstract:
The present invention relates to a Leukocyte-specific protein 1 (LSP1)-deficient T cell-based anticancer immunotherapy. According to the present invention, tumor growth, tumor volume and size were reduced by means of LSP1 knockout, and LSP1 deficiency in T cells increases the number, distribution frequency, migration, and invasion of T cells, and increases the production of an anti-tumor cytokine to inhibit tumor growth and enhance tumor-killing ability. Thus, the present invention can be used for T cell-based immunotherapy.
Inventors:
KIM WAN-UK (KR)
KWON RI-RI (KR)
LEE NA-EUN (KR)
KWON RI-RI (KR)
LEE NA-EUN (KR)
Application Number:
PCT/KR2021/006538
Publication Date:
December 02, 2021
Filing Date:
May 26, 2021
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K48/00; A61K31/7105; A61K31/713; A61K39/00; A61K45/06; A61P35/00; C12N5/0783; C12N15/113; C12Q1/6886; G01N33/68
Foreign References:
| US20190367635A1 | 2019-12-05 | |||
| KR20190142330A | 2019-12-26 | |||
| KR20170074235A | 2017-06-29 |
Other References:
CAO JING-YUAN: "Elevated lymphocyte specific protein 1 expression is involved in the regulation of leukocyte migration and immunosuppressive microenvironment in glioblastoma", AGING, vol. 12, no. 2, 1 January 2020 (2020-01-01), pages 1656 - 1684, XP055871595
HWANG SEONG-HYE, JUNG SEUNG-HYUN, LEE SASEONG, CHOI SUSANNA, YOO SEUNG-AH, PARK JI-HWAN, HWANG DAEHEE, SHIM SEUNG CHEOL, SABBAGH L: "Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 47, 24 November 2015 (2015-11-24), pages E6535 - E6543, XP055871599, ISSN: 0027-8424, DOI: 10.1073/pnas.1514152112
KWON RIRI, HONG BONG-KI, LEE KANG-GU, CHOI EUNBYEOL, SABBAGH LAURENT, CHO CHUL-SOO, LEE NAEUN, KIM WAN-UK: "Regulation of tumor growth by leukocyte-specific protein 1 in T cells", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. e001180, 1 October 2020 (2020-10-01), pages 1 - 16, XP055871602, DOI: 10.1136/jitc-2020-001180
KWON RIRI, HONG BONG-KI, LEE KANG-GU, CHOI EUNBYEOL, SABBAGH LAURENT, CHO CHUL-SOO, LEE NAEUN, KIM WAN-UK: "Regulation of tumor growth by leukocyte-specific protein 1 in T cells", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. e001180, 1 October 2020 (2020-10-01), pages 1 - 16, XP055871602, DOI: 10.1136/jitc-2020-001180
HWANG SEONG-HYE, JUNG SEUNG-HYUN, LEE SASEONG, CHOI SUSANNA, YOO SEUNG-AH, PARK JI-HWAN, HWANG DAEHEE, SHIM SEUNG CHEOL, SABBAGH L: "Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 112, no. 47, 24 November 2015 (2015-11-24), pages E6535 - E6543, XP055871599, ISSN: 0027-8424, DOI: 10.1073/pnas.1514152112
KWON RIRI, HONG BONG-KI, LEE KANG-GU, CHOI EUNBYEOL, SABBAGH LAURENT, CHO CHUL-SOO, LEE NAEUN, KIM WAN-UK: "Regulation of tumor growth by leukocyte-specific protein 1 in T cells", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. e001180, 1 October 2020 (2020-10-01), pages 1 - 16, XP055871602, DOI: 10.1136/jitc-2020-001180
KWON RIRI, HONG BONG-KI, LEE KANG-GU, CHOI EUNBYEOL, SABBAGH LAURENT, CHO CHUL-SOO, LEE NAEUN, KIM WAN-UK: "Regulation of tumor growth by leukocyte-specific protein 1 in T cells", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. e001180, 1 October 2020 (2020-10-01), pages 1 - 16, XP055871602, DOI: 10.1136/jitc-2020-001180
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
Download PDF: