Title:
LUMINESCENT PROTEIN
Document Type and Number:
WIPO Patent Application WO/2024/034619
Kind Code:
A1
Abstract:
According to an embodiment, the present disclosure provides a modified luciferase having improved luminescence intensity, and a use thereof. The present disclosure relates to a modified luciferase derived from a luminous mushroom, or a functional fragment thereof in which a mutation is introduced into at least one among arginine or lysine corresponding to position 26 and valine corresponding to position 161 in the amino acid sequence indicated by SEQ ID NO: 1, and which has an enhanced luminescence compared with the luminescence before the introduction of the mutation. The present disclosure also relates to an isolated nucleic acid encoding the modified luciferase or a functional fragment thereof.
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Inventors:
NAGAI TAKEHARU (JP)
TANAKA SOKI (JP)
OSABE KENJI (JP)
ENTANI TETSUYUKI (JP)
TANAKA SOKI (JP)
OSABE KENJI (JP)
ENTANI TETSUYUKI (JP)
Application Number:
PCT/JP2023/028990
Publication Date:
February 15, 2024
Filing Date:
August 08, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12N15/53; A01H5/00; A01K67/027; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N15/31; C12N15/62; C12N15/63
Foreign References:
| JP2020505028A | 2020-02-20 | |||
| JP2021529536A | 2021-11-04 |
Other References:
ILONDU E M, OKITI A A: "Bioluminescence in mushroom and its application potentials", NIGERIAN JOURNAL OF SCIENCE AND ENVIRONMENT, vol. 14, no. 1, 1 January 2016 (2016-01-01), pages 132 - 139, XP093137695
Attorney, Agent or Firm:
IKEUCHI & PARTNERS (JP)
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