Title:
MANNOSE DERIVATIVE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/001004
Kind Code:
A1
Abstract:
The present invention relates to the technical fields of radiopharmaceutical chemistry and clinical nuclear medicine, and in particular to a mannose derivative and an application thereof. The mannose derivative is an isonitrile-containing mannose derivative which contains different linking groups X and has a structure as shown in a general formula (I). A radioactive preparation obtained by labeling the mannose derivative with radionuclide is high in uptake in tumors and good in tumor/non-target ratio, and is a novel tumor radiopharmaceutical worthy of popularization.
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Inventors:
ZHANG JUNBO (CN)
RUAN QING (CN)
YIN GUANGXING (CN)
WANG XUEBIN (CN)
ZHANG ZHANBIN (CN)
TANG ZHIGANG (CN)
LU JIE (CN)
RUAN QING (CN)
YIN GUANGXING (CN)
WANG XUEBIN (CN)
ZHANG ZHANBIN (CN)
TANG ZHIGANG (CN)
LU JIE (CN)
Application Number:
PCT/CN2022/104832
Publication Date:
January 26, 2023
Filing Date:
July 11, 2022
Export Citation:
Assignee:
UNIV BEIJING NORMAL (CN)
International Classes:
C07H13/04; A61K51/04; A61K103/10; C07F13/00; C07H1/00; C07H5/06; C07H13/08
Foreign References:
| CN113583066A | 2021-11-02 | |||
| CN112175025A | 2021-01-05 | |||
| CN107245087A | 2017-10-13 | |||
| CN111138504A | 2020-05-12 | |||
| CN114031652A | 2022-02-11 |
Other References:
STAIRS SHAUN, NEVES ANDRÉ A., STÖCKMANN HENNING, WAINMAN YELENA A., IRELAND-ZECCHINI HEATHER, BRINDLE KEVIN M., LEEPER FINIAN J.: "Metabolic Glycan Imaging by Isonitrile-Tetrazine Click Chemistry", CHEMBIOCHEM, vol. 14, no. 9, 17 June 2013 (2013-06-17), pages 1063 - 1067, XP055860018, ISSN: 1439-4227, DOI: 10.1002/cbic.201300130
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (CN)
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