Title:
MARKER OF FETAL TROPHOBLAST CELL, IDENTIFICATION METHOD, DETECTION KIT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/087760
Kind Code:
A1
Abstract:
A marker of fetal trophoblast cells, an identification method, a detection kit and the use thereof. The identification method comprises performing dyeing treatment on a sample containing fetal trophoblast cells with a fluorescence-labeled HK2 antibody substance, and then performing fluorescence detection, wherein HK2 positive cells are target cells. The kit comprises a fluorescence-labeled HK2 antibody substance and a cell nucleus dye. The above-mentioned technical solution can sensitively and reliably detect fetal trophoblast cells in the cervical mucus or blood samples of pregnant women in the first trimester, and especially can be used for prenatal diagnosis in early pregnancy.
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Inventors:
SHI QIHUI (CN)
WANG CHUNYING (CN)
WANG CHUNYING (CN)
Application Number:
PCT/CN2018/125798
Publication Date:
May 07, 2020
Filing Date:
December 29, 2018
Export Citation:
Assignee:
SUZHOU JUNHUI BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12Q1/68; C12N5/073
Foreign References:
| CN104894229A | 2015-09-09 | |||
| CN1798853A | 2006-07-05 | |||
| CN108410799A | 2018-08-17 | |||
| CN107236809A | 2017-10-10 |
Other References:
MAGNANI , M. ET AL : "Hexokinase in human chorionic villi", EARLY HUMAN DEVELOPMENT, vol. 11, no. 2, 1 July 1985 (1985-07-01), pages 149 - 156, XP023125845, ISSN: 0378-3782, DOI: 10.1016/0378-3782(85)90102-1
BOILEAU, P.: "Hexokinase Isoenzymes in the Rat Placenta", PLACENTA, vol. 19, 31 December 1998 (1998-12-31), pages 439 - 442, XP055702890
See also references of EP 3875600A4
BOILEAU, P.: "Hexokinase Isoenzymes in the Rat Placenta", PLACENTA, vol. 19, 31 December 1998 (1998-12-31), pages 439 - 442, XP055702890
See also references of EP 3875600A4
Attorney, Agent or Firm:
SHANGHAI SAVVY INTELLECTUAL PROPERTY AGENCY (CN)
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