Title:
MARKER IN HIV AND/OR SIV-INFECTED CELL AND APPLICATION OF MARKER
Document Type and Number:
WIPO Patent Application WO/2023/004994
Kind Code:
A1
Abstract:
A marker in an HIV and/or SIV-infected cell and an application of the marker. The marker is a PLK (polo-like kinase). By inhibiting the activity of a PLK protein or clearing same, the purpose of releasing viruses without activating a repository to is achieved, such that the viruses can be detected in a physiological state, and can also be recognized and cleared by an immune system or a drug in vivo. Enhancing the activity of PLK protein can directly inhibit the release of viruses within an HIV and/or SIV-infected cell. The present invention provides a new target for the diagnosis and antiviral therapy of HIV and/or SIV infection, provides medication basis and guarantee for the early rapid detection and extremely early treatment of virus infection, and has important clinical value.
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Inventors:
LIANG GUOXIN (CN)
SHANG HONG (CN)
SHANG HONG (CN)
Application Number:
PCT/CN2021/122082
Publication Date:
February 02, 2023
Filing Date:
September 30, 2021
Export Citation:
Assignee:
FIRST HOSPITAL CHINA MEDICAL UNIV (CN)
International Classes:
G01N33/569; A61P31/18
Foreign References:
| CN111500706A | 2020-08-07 | |||
| CN109374896A | 2019-02-22 | |||
| EP3636781A1 | 2020-04-15 | |||
| CN101208317A | 2008-06-25 | |||
| CN104069106A | 2014-10-01 | |||
| US20110053944A1 | 2011-03-03 | |||
| US20110229484A1 | 2011-09-22 |
Other References:
GOHDA JIN, SUZUKI KAZUO, LIU KAI, XIE XIALIN, TAKEUCHI HIROAKI, INOUE JUN-ICHIRO, KAWAGUCHI YASUSHI, ISHIDA TAKAOMI: "BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1", SCIENTIFIC REPORTS, vol. 8, no. 1, XP093029395, DOI: 10.1038/s41598-018-21942-5
Attorney, Agent or Firm:
SHENYANG YATAI PATENT AND TRADEMARK AGENT CO., LTD. (CN)
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