MECHANISTIC TARGET OF RAPAMYCIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF

Title:

MECHANISTIC TARGET OF RAPAMYCIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC APPLICATIONS THEREOF

Document Type and Number:

WIPO Patent Application WO/2017/219800

Kind Code:

A1

Abstract:

Selective mTOR inhibitors of formulas (I)-(III), processes for their preparation, pharmaceutical compositions containing them, and their use in the treatment of diseases and disorders, arising from abnormal cell growth, functions, or behaviors mediated by an mTOR kinase and/or one or more PI3K enzyme, are provided. Such diseases and disorder include cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

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Inventors:

GUO CHUANGXIN (US)
TONG YOUZHI (US)

Application Number:

PCT/CN2017/084683

Publication Date:

December 28, 2017

Filing Date:

May 17, 2017

Export Citation:

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Assignee:

SUZHOU KINTOR PHARMACEUTICALS INC (CN)

International Classes:

A61K31/5377; C07D487/04; A61P35/00; C07D519/00

Foreign References:

CN103450204A	2013-12-18
CN102675323A	2012-09-19
CN102558185A	2012-07-11

Other References:

DUGAR, S. ET AL.: "Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, no. 16, 10 June 2015 (2015-06-10), pages 3142 - 3146, XP055226049

Attorney, Agent or Firm:

UNITALEN ATTORNEYS AT LAW (CN)

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