Title:
MEDICINAL COMPOSITION FOR TREATING INTRACTABLE HEART DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/124236
Kind Code:
A1
Abstract:
Provided is a medicinal composition to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure. The medicinal composition, which is to be used for treating an intractable heart tissue fibrosis disease accompanying chronic heart failure, comprises as an active ingredient at least one member selected from the group consisting of a protease inhibitor, a thromboxane A2 synthase inhibitor and an antagonist thereof, a phosphodiesterase (PDE) inhibitor, a tyrosine kinase inhibitor, an HMG-CoA reductase inhibitor and an anti-fibrosis agent. (Said medicinal composition includes a sustainable preparation thereof enclosed in a biodegradable polymer.)
Inventors:
SAWA YOSHIKI (JP)
MIYAGAWA SHIGERU (JP)
SAKAI YOSHIKI (JP)
YANAGI YASUHIRO (JP)
MIYAGAWA SHIGERU (JP)
SAKAI YOSHIKI (JP)
YANAGI YASUHIRO (JP)
Application Number:
PCT/JP2017/047100
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
UNIV OSAKA (JP)
CARDIO INCORPORATED (JP)
CARDIO INCORPORATED (JP)
International Classes:
A61K45/06; A61K9/14; A61K9/50; A61K9/70; A61K31/24; A61K31/366; A61K31/4174; A61K31/4418; A61K31/4709; A61K31/496; A61K31/519; A61K31/522; A61L15/40; A61L15/64; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P43/00; C07D209/34; C07D213/64; C07D233/60; C07D309/30; C07D401/12; C07D473/08; C07D487/04
Domestic Patent References:
| WO2004100988A1 | 2004-11-25 | |||
| WO2008047863A1 | 2008-04-24 | |||
| WO2004032965A1 | 2004-04-22 | |||
| WO2008047863A1 | 2008-04-24 | |||
| WO2014046065A1 | 2014-03-27 | |||
| WO2014069401A1 | 2014-05-08 |
Foreign References:
| JP2012515800A | 2012-07-12 | |||
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Other References:
YATABE, SAKON: "Effect of Cilostazol in a patient with heart failure caused by Bradyarrhythmia (non official translation)", JOURNAL OF JAPAN PHYSICIANS ASSOCIATION, vol. 21, no. 4, 2006, pages 426 - 430, XP9515327
TSUCHIYA, KEN: "A patient with dilated hypertropic cardiomyopathy who improved sinus bradycaria and heart insufficiency after prescription of cilostazol", RINSHŌ-TO-KENKYŪ = THE JAPANESE JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 83, no. 5, 2006, pages 753 - 758, XP009515328, ISSN: 0021-4965
OGURA, TOSHITSUGU ET AL: "Effects of oky-046, a selective thromboxane A2 synthetase inhibitor, on venticular arrhythmias and prostaglandins during coronary artery ", JAPANESE J. PHARMACOL, vol. 47, no. 1, 1 January 1988 (1988-01-01), pages 95 - 98, XP055612581, DOI: 10.1254/jjp.47.95
FUJIMURA, MASAKI: "non official translation; Medical treatment-thromboxane A2 inhibitor", RESPIRATION, vol. 9, no. 9, pages 1114 - 1120
SASAKI, SHINICHI: "The specified disease treatment research program in terms of idiopathic interstitial pneumonias", THE MEDICAL FRONTLINE, vol. 71, no. 7, 1 July 2016 (2016-07-01), pages 128 - 137, XP9515330
OKUNO, MASATAKA ET AL.: "S5-5: Inhibition of liver fibrosis by serine protease inhibitor", KANZO = ACTA HEPATOLOGICA JAPONICA, vol. 43, no. suppl. 2, 2002, pages A269, XP009515329
SURG. TODAY, vol. 42, 2012, pages 181 - 184
ANN. THORAC. SURG., vol. 91, 2011, pages 320 - 9
HEART FAIL REV., vol. 20, 2015, pages 401 - 413
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 145040-37-5
See also references of EP 3569249A4
TSUCHIYA, KEN: "A patient with dilated hypertropic cardiomyopathy who improved sinus bradycaria and heart insufficiency after prescription of cilostazol", RINSHŌ-TO-KENKYŪ = THE JAPANESE JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 83, no. 5, 2006, pages 753 - 758, XP009515328, ISSN: 0021-4965
OGURA, TOSHITSUGU ET AL: "Effects of oky-046, a selective thromboxane A2 synthetase inhibitor, on venticular arrhythmias and prostaglandins during coronary artery ", JAPANESE J. PHARMACOL, vol. 47, no. 1, 1 January 1988 (1988-01-01), pages 95 - 98, XP055612581, DOI: 10.1254/jjp.47.95
FUJIMURA, MASAKI: "non official translation; Medical treatment-thromboxane A2 inhibitor", RESPIRATION, vol. 9, no. 9, pages 1114 - 1120
SASAKI, SHINICHI: "The specified disease treatment research program in terms of idiopathic interstitial pneumonias", THE MEDICAL FRONTLINE, vol. 71, no. 7, 1 July 2016 (2016-07-01), pages 128 - 137, XP9515330
OKUNO, MASATAKA ET AL.: "S5-5: Inhibition of liver fibrosis by serine protease inhibitor", KANZO = ACTA HEPATOLOGICA JAPONICA, vol. 43, no. suppl. 2, 2002, pages A269, XP009515329
SURG. TODAY, vol. 42, 2012, pages 181 - 184
ANN. THORAC. SURG., vol. 91, 2011, pages 320 - 9
HEART FAIL REV., vol. 20, 2015, pages 401 - 413
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 145040-37-5
See also references of EP 3569249A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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