Title:
MEDICINAL COMPOSITION FOR TREATMENT FOR OR PREVENTION OF VISCERAL PAIN
Document Type and Number:
WIPO Patent Application WO/2004/029057
Kind Code:
A1
Abstract:
A pyrrolopyridazine compound having a structure represented by the general formula (I) (wherein R1 represents alkenyl, halogenoalkenyl, alkynyl, cycloalkyl, or optionally substituted cycloalkylalkyl; R2 represents hydrogen or alkyl; R3 represents hydrogen, alkyl, or hydroxyalkyl; R4 represents hydrogen or alkyl; R5 represents optionally substituted phenyl; A represents alkylene; and X represents oxygen or sulfur), a pharmacologically acceptable salt of the compound, or a pharmacologically acceptable ester of the compound. They are useful as a medicine for treatments for or prevention of visceral pain.
Inventors:
ITO KEIICHI (JP)
KINOSHITA KAZUYA (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
KINOSHITA KAZUYA (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
Application Number:
PCT/JP2003/012262
Publication Date:
April 08, 2004
Filing Date:
September 25, 2003
Export Citation:
Assignee:
SANKYO CO (JP)
UBE INDUSTRIES (JP)
ITO KEIICHI (JP)
KINOSHITA KAZUYA (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
UBE INDUSTRIES (JP)
ITO KEIICHI (JP)
KINOSHITA KAZUYA (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
International Classes:
A61K31/5025; A61P1/06; C07D487/04; (IPC1-7): C07D487/04; A61K31/5025; A61P1/06
Domestic Patent References:
| WO2001058901A1 | 2001-08-16 | |||
| WO2000077003A1 | 2000-12-21 | |||
| WO1999028322A1 | 1999-06-10 | |||
| WO1995019980A1 | 1995-07-27 | |||
| WO1993008190A1 | 1993-04-29 | |||
| WO1992006979A1 | 1992-04-30 | |||
| WO1991017164A1 | 1991-11-14 | |||
| WO2000037043A1 | 2000-06-29 | |||
| WO2001044815A1 | 2001-06-21 |
Foreign References:
| JP2002241285A | 2002-08-28 | |||
| JP2003119140A | 2003-04-23 | |||
| JP2002068992A | 2002-03-08 |
Other References:
HISAYOSHI ONUKI: "Hukutsu no Taisho Ryoho no Kangaekata Okonaikata", MEDICINA, vol. 28, no. 4, 1991, pages 570 - 573, XP002977452
GEBHART, G. F.: "Central mechanisms of visceral pain.", CAN. J. PHYSIOL. PHARMACOL., vol. 69, no. 5, 1991, pages 627 - 634, XP002977453
GEBHART, G. F.: "Central mechanisms of visceral pain.", CAN. J. PHYSIOL. PHARMACOL., vol. 69, no. 5, 1991, pages 627 - 634, XP002977453
Attorney, Agent or Firm:
Nakamura, Minoru (Shin-Tokyo Building 3-1, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)
Download PDF:
Previous Patent: [1,2,4]-TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVE
Next Patent: MEDICINAL COMPOSITION FOR INHIBITING INCREASE IN BLOOD GASTRIN CONCENTRATION
Next Patent: MEDICINAL COMPOSITION FOR INHIBITING INCREASE IN BLOOD GASTRIN CONCENTRATION