Title:
MEDICINAL COMPOSITION FOR INHIBITING INCREASE IN BLOOD GASTRIN CONCENTRATION
Document Type and Number:
WIPO Patent Application WO/2004/029058
Kind Code:
A1
Abstract:
A pyrrolopyridazine compound having a structure represented by the general formula (I) (wherein R1 represents alkenyl, halogenoalkenyl, alkynyl, cycloalkyl, or optionally substituted cycloalkylalkyl; R2 represents hydrogen or alkyl; R3 represents hydrogen, alkyl, or hydroxyalkyl; R4 represents hydrogen or alkyl; R5 represents optionally substituted phenyl; A represents alkylene; and X represents oxygen or sulfur), a pharmacologically acceptable salt of the compound, or a pharmacologically acceptable ester of the compound. They are useful as a medicine for inhibiting the increase of blood gastrin concentration. Also provided is a medicinal composition comprising any of the pyrrolopyridazine compound, pharmacologically acceptable salt, and pharmacologically acceptable ester and a gastric hydrochloric acid secretoinhibitor having a benzimidazole skeleton. The composition is useful as a medicine for treatments for or prevention of ulcerative diseases which is reduced in side effects.
Inventors:
ITO KEIICHI (JP)
TOMIZAWA ATSUYUKI (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
TOMIZAWA ATSUYUKI (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
Application Number:
PCT/JP2003/012263
Publication Date:
April 08, 2004
Filing Date:
September 25, 2003
Export Citation:
Assignee:
SANKYO CO (JP)
UBE INDUSTRIES (JP)
ITO KEIICHI (JP)
TOMIZAWA ATSUYUKI (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
UBE INDUSTRIES (JP)
ITO KEIICHI (JP)
TOMIZAWA ATSUYUKI (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
International Classes:
A61K31/5025; A61P1/04; A61P43/00; C07D487/04; (IPC1-7): C07D487/04; A61K31/5025; A61P1/04; A61P43/00
Domestic Patent References:
| WO2001058901A1 | 2001-08-16 | |||
| WO2000077003A1 | 2000-12-21 | |||
| WO1999028322A1 | 1999-06-10 | |||
| WO1995019980A1 | 1995-07-27 | |||
| WO1993008190A1 | 1993-04-29 | |||
| WO1992009679A1 | 1992-06-11 | |||
| WO1991017164A1 | 1991-11-14 |
Foreign References:
| JP2002241285A | 2002-08-28 | |||
| JP2003119140A | 2003-04-23 | |||
| JP2002068992A | 2002-03-08 |
Other References:
NOBURO KOMURA: "San Bunpitsu Yokusei jotai ni okeru Inai Bunpitsu Dotai to Ensan Pirenzepine", SHOKASEI KAIYO -RINSHO TO KISO, vol. 16, no. 1, 1997, pages 47 - 53, XP002977445
TOSHIYUKI KATO: "Proton Pump Sogaizai ni Yoru Ko-Gastrine Kessho ni taisuru Enprostil (PGE2) Heiyo Koka no Kento", PROG. MED., vol. 15, no. 9, 1995, pages 1880 - 1885, XP002977446
YUMIKO ISHINO: "Proton Pump Sogaiyaku", MEDICINA, vol. 37, no. 12, 2000, pages 1743 - 1745, XP002977447
TOSHIYUKI KATO: "Proton Pump Sogaizai ni Yoru Ko-Gastrine Kessho ni taisuru Enprostil (PGE2) Heiyo Koka no Kento", PROG. MED., vol. 15, no. 9, 1995, pages 1880 - 1885, XP002977446
YUMIKO ISHINO: "Proton Pump Sogaiyaku", MEDICINA, vol. 37, no. 12, 2000, pages 1743 - 1745, XP002977447
Attorney, Agent or Firm:
Nakamura, Minoru (Shin-Tokyo Building 3-1, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)
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