Title:
MEDICINAL USE OF FINGOLIMOD IN PREVENTING AND TREATING NEURODEGENERATIVE DISEASES CAUSED BY SPHINGOLIPID DISORDERS
Document Type and Number:
WIPO Patent Application WO/2022/095610
Kind Code:
A1
Abstract:
Provided is a medicinal use of fingolimod in preventing and treating neurodegenerative diseases caused by sphingolipid disorders. Research has shown that fingolimod can effectively alleviate and significantly improve the motion function of spastic paraplegic mice, enable old paraplegic mice to stand again, and increase the number of times paraplegic mice stand. Meanwhile, the present invention can effectively reduce/lower lipofuscin deposition and myelin tear in mouse brain tissue, can significantly alleviate the reduction or deficiency of sphingomyelin, promote the recycling of sphingomyelin, and correct neurological dysfunction caused by sphingolipid disorders that are due to a sphingomyelin deficiency. Further provided is an application of fingolimod in the preparation of a drug for preventing and treating neurodegenerative diseases caused by sphingolipid disorders. Fingolimod can be used to prevent and treat neurodegenerative diseases, such as spastic paraplegia, amyotrophic lateral sclerosis, corticobasal degeneration, spinocerebellar ataxia, and diseases within the category of neuronal ceroid lipofuscinosis, caused by sphingolipid disorders.
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Inventors:
LIU JUNPING (CN)
Application Number:
PCT/CN2021/118796
Publication Date:
May 12, 2022
Filing Date:
September 16, 2021
Export Citation:
Assignee:
HANGZHOU DUANLI BIOTECHNOLOGY COMPANY LTD (CN)
International Classes:
A61P3/00; A61K31/137; A61P25/00; A61P25/28
Foreign References:
| CN112237575A | 2021-01-19 | |||
| CN108642129A | 2018-10-12 | |||
| CN111455019A | 2020-07-28 | |||
| US20130150454A1 | 2013-06-13 |
Other References:
BASCUÑANA PABLO, MÖHLE LUISA, BRACKHAN MIRJAM, PAHNKE JENS: "Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis", DRUGS IN R&D, ADIS INTERNATIONAL LTD , NZL, vol. 20, no. 3, 1 September 2020 (2020-09-01), pages 197 - 207, XP055928414, ISSN: 1174-5886, DOI: 10.1007/s40268-020-00316-1
WEN-BIN WANG, JIAN-XIN QIU: "Mechanism and clinical application of fi ngolimod in the central nervous system diseases", WORLD CLINICAL DRUGS, vol. 38, no. 8, 31 August 2017 (2017-08-31), pages 1 - 5, XP055928406, DOI: 10.13683/j.wph.2017.08.015
WEN-BIN WANG, JIAN-XIN QIU: "Mechanism and clinical application of fi ngolimod in the central nervous system diseases", WORLD CLINICAL DRUGS, vol. 38, no. 8, 31 August 2017 (2017-08-31), pages 1 - 5, XP055928406, DOI: 10.13683/j.wph.2017.08.015
Attorney, Agent or Firm:
HANGZHOU QIUSHI PATENT OFFICE CO., LTD. (CN)
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