Title:
MEDICINE COMPRISING COMBINATION OF ANTI-MUTANT-CALR ANTIBODY AND ANOTHER DRUG
Document Type and Number:
WIPO Patent Application WO/2023/163087
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a medicine exhibiting a satisfactory anti-cancer effect by combining an antibody capable of binding to a mutant CALR protein with another anti-cancer agent. Provided is a medicine for preventing and/or treating cancer, the medicine comprising a combination of (A) an antibody capable of binding specifically to a mutant calreticulin protein or a functional fragment thereof and (B) at least one drug selected from an alkylating agent, a platinum preparation, an antimetabolite, a ribonucleotide reductase inhibitor, a nucleotide analogue, a topoisomerase inhibitor, a microtubule assembly inhibiting drug, an anti-tumor antibiotic, an interferon, a cytokine preparation, a molecule targeting drug, a nucleic acid synthesis inhibitor, a JAK inhibitor and an immuno-oncology drug.
Inventors:
KOMATSU NORIO (JP)
ISHIDA YOJI (JP)
ARAKI MARITO (JP)
TSUCHIYA TOSHIYUKI (JP)
CHIKADA TSUBASA (JP)
IMAI MISA (JP)
FUKASAWA HIROSHI (JP)
ISHIDA YOJI (JP)
ARAKI MARITO (JP)
TSUCHIYA TOSHIYUKI (JP)
CHIKADA TSUBASA (JP)
IMAI MISA (JP)
FUKASAWA HIROSHI (JP)
Application Number:
PCT/JP2023/006642
Publication Date:
August 31, 2023
Filing Date:
February 24, 2023
Export Citation:
Assignee:
JUNTENDO EDUCATIONAL FOUND (JP)
MEIJI SEIKA PHARMA CO LTD (JP)
MEIJI SEIKA PHARMA CO LTD (JP)
International Classes:
A61K39/395; A61K31/17; A61K31/519; A61K38/21; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07K16/46; C07K16/18
Domestic Patent References:
| WO2020175689A1 | 2020-09-03 |
Foreign References:
| US20170269092A1 | 2017-09-21 |
Other References:
NASILLO VINCENZO, RIVA GIOVANNI, PAOLINI AMBRA, FORGHIERI FABIO, RONCATI LUCA, LUSENTI BEATRICE, MACCAFERRI MONICA, MESSEROTTI AND: "Inflammatory Microenvironment and Specific T Cells in Myeloproliferative Neoplasms: Immunopathogenesis and Novel Immunotherapies", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 4, 14 February 2021 (2021-02-14), pages 1906, XP093087215, DOI: 10.3390/ijms22041906
Attorney, Agent or Firm:
ARUGA PATENT OFFICE (JP)
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