Title:
MESENCHYMAL STEM CELL, EXTRACELLULAR VESICLE ISOLATED THEREFROM, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/282423
Kind Code:
A1
Abstract:
The present invention relates to mesenchymal stem cells, extracellular vesicles isolated therefrom, and a use thereof. The mesenchymal stem cells of the present invention exhibit upregulated expression levels of at least one marker selected from among SPP1, PLAU, ITGA6, CENPI, and BUB1 and/or a downregulated expression level of the marker PTGS2, thereby remarkably decreasing levels of inflammatory cytokines such as TNF-α, IL-6, etc., and are therefore effective for preventing, ameliorating, alleviating, or treating various inflammatory diseases. Specifically, when administered into interstitial cystitis/bladder pain syndrome (IC/BPS) animal models, the mesenchymal stem cells or stem cell-derived extracellular vesicles isolated therefrom of the present invention restore the inner bladder wall broken down in the IC/BPS induction process and palliate inflammation, thus exhibiting excellent therapeutic efficacy for interstitial cystitis/bladder pain syndrome. In addition, the mesenchymal stem cells or the stem cell-derived extracellular vesicles isolated therefrom of the present invention has excellent wound healing effects and thus can be advantageously used for wound healing.
Inventors:
CHO SSANG-GOO (KR)
LIM KYUNG MIN (KR)
ABDEL DAYEM AHMED (KR)
LEE SOO BIN (KR)
CHOI YUJIN (KR)
KANG GEUN-HO (KR)
KIM ARAM (KR)
LIM KYUNG MIN (KR)
ABDEL DAYEM AHMED (KR)
LEE SOO BIN (KR)
CHOI YUJIN (KR)
KANG GEUN-HO (KR)
KIM ARAM (KR)
Application Number:
PCT/KR2022/001337
Publication Date:
January 12, 2023
Filing Date:
January 25, 2022
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
STEMEXONE LTD (KR)
KONKUK UNIV GLOCAL IND ACADEMIC COLLABORATION FOUND (KR)
STEMEXONE LTD (KR)
KONKUK UNIV GLOCAL IND ACADEMIC COLLABORATION FOUND (KR)
International Classes:
C12N5/0775; A61K35/28; A61P13/10; A61P17/02; A61P29/00; C12M1/42; C12N13/00
Foreign References:
| KR20160108190A | 2016-09-19 | |||
| KR20110127111A | 2011-11-24 |
Other References:
ZHANG SHICHANG; LIU PING; CHEN LI; WANG YINGJIE; WANG ZHENGGUO; ZHANG BO: "The effects of spheroid formation of adipose-derived stem cells in a microgravity bioreactor on stemness properties and therapeutic potential", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 41, 1 December 2014 (2014-12-01), AMSTERDAM, NL , pages 15 - 25, XP029116876, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2014.11.019
ABDAL DAYEM AHMED, KIM KYEONGSEOK, LEE SOO BIN, KIM ARAM, CHO SSANG-GOO: "Application of Adult and Pluripotent Stem Cells in Interstitial Cystitis/Bladder Pain Syndrome Therapy: Methods and Perspectives", JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 3, 12 March 2020 (2020-03-12), pages 766, XP093022752, DOI: 10.3390/jcm9030766
KIM BUM SOO; CHUN SO YOUNG; LEE EUN HYE; CHUNG JAE-WOOK; LEE JUN NYUNG; HA YUN-SOK; CHOI JAE YOUNG; SONG PHIL HYUN; KWON TAE GYUN;: "Efficacy of combination therapy with pentosan polysulfate sodium and adipose tissue-derived stem cells for the management of interstitial cystitis in a rat model", STEM CELL RESEARCH, ELSEVIER, NL, vol. 45, 21 April 2020 (2020-04-21), NL , XP086164993, ISSN: 1873-5061, DOI: 10.1016/j.scr.2020.101801
ABDAL DAYEM AHMED, KIM KYEONGSEOK, LEE SOO BIN, KIM ARAM, CHO SSANG-GOO: "Application of Adult and Pluripotent Stem Cells in Interstitial Cystitis/Bladder Pain Syndrome Therapy: Methods and Perspectives", JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 3, 12 March 2020 (2020-03-12), pages 766, XP093022752, DOI: 10.3390/jcm9030766
KIM BUM SOO; CHUN SO YOUNG; LEE EUN HYE; CHUNG JAE-WOOK; LEE JUN NYUNG; HA YUN-SOK; CHOI JAE YOUNG; SONG PHIL HYUN; KWON TAE GYUN;: "Efficacy of combination therapy with pentosan polysulfate sodium and adipose tissue-derived stem cells for the management of interstitial cystitis in a rat model", STEM CELL RESEARCH, ELSEVIER, NL, vol. 45, 21 April 2020 (2020-04-21), NL , XP086164993, ISSN: 1873-5061, DOI: 10.1016/j.scr.2020.101801
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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