Title:
MESENCHYMAL STEM CELL INDUCER, TISSUE REGENERATION PROMOTER AND METHOD OF PREPARING MESENCHYMAL STEM CELL
Document Type and Number:
WIPO Patent Application WO/2007/015546
Kind Code:
A1
Abstract:
A mesenchymal stem cell inducer of the invention contains BMP-2 and is characterized in that it increases mesenchymal stem cells in the blood. A tissue regeneration promoter of the invention contains BMP-2 and is systemically administered, and is characterized in that it increases a mesenchymal stem cell in the blood. A method of preparing mesenchymal stem cells of the invention is characterized by comprising the steps of administering BMP-2 to a non-human animal, collecting the blood containing mesenchymal stem cells and isolating mesenchymal stem cells from the collected blood.
Inventors:
TAMAI KATSUTO (JP)
OTSURU SATORU (JP)
KANEDA YASUFUMI (JP)
OTSURU SATORU (JP)
KANEDA YASUFUMI (JP)
Application Number:
PCT/JP2006/315406
Publication Date:
February 08, 2007
Filing Date:
August 03, 2006
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
TAMAI KATSUTO (JP)
OTSURU SATORU (JP)
KANEDA YASUFUMI (JP)
TAMAI KATSUTO (JP)
OTSURU SATORU (JP)
KANEDA YASUFUMI (JP)
International Classes:
C12N5/00; A61K38/22; A61P43/00; C12N5/06; C12N15/09
Other References:
ALDEN T.D. ET AL.: "In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector", HUM. GENE THER., vol. 10, 1999, pages 2245 - 2253, XP002355896
SUN S. ET AL.: "Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method", STEM CELLS, vol. 21, 2003, pages 527 - 535, XP003007847
OTSURU S. ET AL.: "BMP-2 mobilizes robust bone marrow mesenchymal progenitor cells to the circulating blood in bone regeneration", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN KOEN YOSHISHU, vol. 28, 25 November 2005 (2005-11-25), pages 733 + ABS. NO. 3P-1012, XP003007848
SUN S. ET AL.: "Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method", STEM CELLS, vol. 21, 2003, pages 527 - 535, XP003007847
OTSURU S. ET AL.: "BMP-2 mobilizes robust bone marrow mesenchymal progenitor cells to the circulating blood in bone regeneration", ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN KOEN YOSHISHU, vol. 28, 25 November 2005 (2005-11-25), pages 733 + ABS. NO. 3P-1012, XP003007848
Attorney, Agent or Firm:
HASEGAWA, Yoshiki et al. (Ginza First Bldg. 10-6, Ginza 1-chom, Chuo-ku Tokyo 61, JP)
Download PDF: