Title:
MESENCHYMAL STEM CELLS AND ADIPOCYTES FOR PREPARING MITOKINE MIXTURE, AND THERAPEUTIC OR PROPHYLACTIC DRUG
Document Type and Number:
WIPO Patent Application WO/2022/176917
Kind Code:
A1
Abstract:
Provided are: a non-human animal or a part of the same in which the function of Mipep gene is totally or partially lost in adipose tissues or the expression level of Mipep gene in adipose tissues is lowered compared to a wild type; and mesenchymal stem cells or adipocytes in which the function of Mipep gene is totally or partially lost or the expression level of Mipep gene is lowered compared to a wild type. Also provided are: a therapeutic or prophylactic drug that comprises the aforesaid mesenchymal stem cells or adipocytes or a culture supernatant thereof; and a method for preparing a mitokine mixture using the aforesaid non-human cells, mesenchymal stem cells or adipocytes.
Inventors:
HIGAMI YOSHIKAZU (JP)
KOBAYASHI MASAKI (JP)
NARITA TAKUMI (JP)
TAKI KANARI (JP)
HIRAO YUTO (JP)
KOBAYASHI MASAKI (JP)
NARITA TAKUMI (JP)
TAKI KANARI (JP)
HIRAO YUTO (JP)
Application Number:
PCT/JP2022/006200
Publication Date:
August 25, 2022
Filing Date:
February 16, 2022
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
C12N5/10; A61K35/28; A61K35/35; A61P3/04; A61P9/10; A61P13/12; A61P29/00; A61P31/04; C07K14/475; C07K14/50; C12N5/077; C12N5/0775; C12N15/90; C12P21/02; A01K67/027
Domestic Patent References:
| WO2017188403A1 | 2017-11-02 |
Other References:
CHOI MIN JEONG; JUNG SAET-BYEL; LEE SEONG EUN; KANG SEUL GI; LEE JU HEE; RYU MIN JEONG; CHUNG HYO KYUN; CHANG JOON YOUNG; KIM YONG: "An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models", DIABETOLOGIA, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 63, no. 4, 10 January 2020 (2020-01-10), Berlin/Heidelberg, pages 837 - 852, XP037047343, ISSN: 0012-186X, DOI: 10.1007/s00125-019-05082-7
KANG SEUL GI, YI HYON-SEUNG, CHOI MIN JEONG, RYU MIN JEONG, JUNG SAETBYEL, CHUNG HYO KYUN, CHANG JOON YOUNG, KIM YONG KYUNG, LEE S: "ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21", JOURNAL OF ENDOCRINOLOGY, JOURNAL OF ENDOCRINOLOGY, vol. 233, no. 1, 1 April 2017 (2017-04-01), pages 105 - 118, XP055959463, ISSN: 0022-0795, DOI: 10.1530/JOE-16-0549
M. J. H. COENEN ; J. A. M. SMEITINK ; R. SMEETS ; F. J. M. TRIJBELS ; L. P. VAN DEN HEUVEL: "Mutation detection in four candidate genes (OXA1L, MRS2L, YME1L and MIPEP) for combined deficiencies in the oxidative phosphorylation system", JOURNAL OF INHERITED METABOLIC DISEASE, KLUWER ACADEMIC PUBLISHERS, DO, vol. 28, no. 6, 1 December 2005 (2005-12-01), Do , pages 1091 - 1097, XP019232704, ISSN: 1573-2665, DOI: 10.1007/s10545-005-4483-y
ELDOMERY MOHAMMAD K., AKDEMIR ZEYNEP C., VÖGTLE F.-NORA, CHARNG WU-LIN, MULICA PATRYCJA, ROSENFELD JILL A., GAMBIN TOMASZ, GU SHEN: "MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death", GENOME MEDICINE, vol. 8, no. 1, 1 December 2016 (2016-12-01), XP055959465, DOI: 10.1186/s13073-016-0360-6
KOBAYASHI MASAKI, NEZU YUICHIRO, TAGAWA RYOMA, HIGAMI YOSHIKAZU: "Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 6, 1 January 2021 (2021-01-01), pages 2854, XP055959467, DOI: 10.3390/ijms22062854
LUAN ET AL., CELL, vol. 178, 2019, pages 1231 - 1244
KEMPF ET AL., CIRC. RES., vol. 98, 2006, pages 351 - 360
KANG, PHARMACOTHER, vol. 129, 2020, pages 110439
SUN ET AL., J. CELL BIOCHEM., vol. 120, no. 12, 2019, pages 19529 - 19540
KOBAYASHI ET AL., FEBS LETTERS, vol. 591, 2017, pages 4067 - 4073
KANKI ET AL., EXP. ANIM., vol. 55, 2006, pages 137 - 141
KANG SEUL GI, YI HYON-SEUNG, CHOI MIN JEONG, RYU MIN JEONG, JUNG SAETBYEL, CHUNG HYO KYUN, CHANG JOON YOUNG, KIM YONG KYUNG, LEE S: "ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21", JOURNAL OF ENDOCRINOLOGY, JOURNAL OF ENDOCRINOLOGY, vol. 233, no. 1, 1 April 2017 (2017-04-01), pages 105 - 118, XP055959463, ISSN: 0022-0795, DOI: 10.1530/JOE-16-0549
M. J. H. COENEN ; J. A. M. SMEITINK ; R. SMEETS ; F. J. M. TRIJBELS ; L. P. VAN DEN HEUVEL: "Mutation detection in four candidate genes (OXA1L, MRS2L, YME1L and MIPEP) for combined deficiencies in the oxidative phosphorylation system", JOURNAL OF INHERITED METABOLIC DISEASE, KLUWER ACADEMIC PUBLISHERS, DO, vol. 28, no. 6, 1 December 2005 (2005-12-01), Do , pages 1091 - 1097, XP019232704, ISSN: 1573-2665, DOI: 10.1007/s10545-005-4483-y
ELDOMERY MOHAMMAD K., AKDEMIR ZEYNEP C., VÖGTLE F.-NORA, CHARNG WU-LIN, MULICA PATRYCJA, ROSENFELD JILL A., GAMBIN TOMASZ, GU SHEN: "MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hypotonia, and infantile death", GENOME MEDICINE, vol. 8, no. 1, 1 December 2016 (2016-12-01), XP055959465, DOI: 10.1186/s13073-016-0360-6
KOBAYASHI MASAKI, NEZU YUICHIRO, TAGAWA RYOMA, HIGAMI YOSHIKAZU: "Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 6, 1 January 2021 (2021-01-01), pages 2854, XP055959467, DOI: 10.3390/ijms22062854
LUAN ET AL., CELL, vol. 178, 2019, pages 1231 - 1244
KEMPF ET AL., CIRC. RES., vol. 98, 2006, pages 351 - 360
KANG, PHARMACOTHER, vol. 129, 2020, pages 110439
SUN ET AL., J. CELL BIOCHEM., vol. 120, no. 12, 2019, pages 19529 - 19540
KOBAYASHI ET AL., FEBS LETTERS, vol. 591, 2017, pages 4067 - 4073
KANKI ET AL., EXP. ANIM., vol. 55, 2006, pages 137 - 141
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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