Title:
METAL COMPLEXES OF POLYAMINOACIDS, AND THEIR UTILIZATION IN DIAGNOSTIC IMAGING
Document Type and Number:
WIPO Patent Application WO1997001359
Kind Code:
A3
Abstract:
PCT No. PCT/FR96/00992 Sec. 371 Date Dec. 29, 1997 Sec. 102(e) Date Dec. 29, 1997 PCT Filed Jun. 25, 1996 PCT Pub. No. WO97/01359 PCT Pub. Date Jan. 16, 1997The invention concerns gadolinium complexes of formula: I in which R represents a group of formula: in which X is Br or I; R1 is H or optionally hydroxylated alkyl; R2 is hydroxylated alkyl; or alternatively R1 is H and R2 is a group of formula: A X being as defined above, and R'1 and R'2 being as defined for R1 and R2 excepted that they do not represent A, provided that -CO-NR1R2 or -CO-NR'1R'2 comprises at least 2 hydroxyl groups, and M represents H or the cation of an inorganic or organic base.
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Inventors:
MEYER DOMINIQUE (FR)
ROUSSEAUX OLIVIER (FR)
SCHAEFER MICHEL (FR)
SIMONOT CHRISTIAN (FR)
ROUSSEAUX OLIVIER (FR)
SCHAEFER MICHEL (FR)
SIMONOT CHRISTIAN (FR)
Application Number:
PCT/FR1996/000992
Publication Date:
May 22, 1997
Filing Date:
June 25, 1996
Export Citation:
Assignee:
GUERBET SA (FR)
MEYER DOMINIQUE (FR)
ROUSSEAUX OLIVIER (FR)
SCHAEFER MICHEL (FR)
SIMONOT CHRISTIAN (FR)
MEYER DOMINIQUE (FR)
ROUSSEAUX OLIVIER (FR)
SCHAEFER MICHEL (FR)
SIMONOT CHRISTIAN (FR)
International Classes:
A61K49/00; A61K49/04; A61K49/08; C07D257/02; (IPC1-7): A61K49/00; A61K49/04
Domestic Patent References:
| WO1994027644A1 | 1994-12-08 | |||
| WO1993016375A1 | 1993-08-19 |
Foreign References:
| EP0414287A1 | 1991-02-27 |
Other References:
PENG C T: "CHAPITRE 61: RADIOPAQUES", M.E. WOLFF (ED.): BURGER'S MEDICINAL CHEMISTRY, EDITION 4, PARTIE III, 1979, J. WILEY & SONS, NEW YORK, US, pages 1139 - 1203, XP002005069
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