Title:
METHOD OR AGENT WITH HDAC REGULATOR, FOR TREATMENT OF DIABETES AND COMPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2023/074794
Kind Code:
A1
Abstract:
The present disclosure provides a novel treatment for diabetes. The present disclosure provides a treatment for diabetes, in which blood sugar control and HDAC adjustment are combined. According to one embodiment, the present disclosure provides a treatment for diabetes and/or diseases, disorders, and/or symptoms related to diabetes, in which blood sugar control and HDAC adjustment are combined. According to one embodiment, blood sugar control and HDAC adjustment are combined to set abnormal stem cells as a target, to treat diabetes and/or diseases, disorders and/or symptoms related to diabetes.
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Inventors:
KOJIMA HIDETO (JP)
KATAGI MIWAKO (JP)
KATAGI MIWAKO (JP)
Application Number:
PCT/JP2022/040140
Publication Date:
May 04, 2023
Filing Date:
October 27, 2022
Export Citation:
Assignee:
NATIONAL UNIV CORPORATION SHIGA UNIV OF MEDICAL SCIENCE (JP)
International Classes:
A61K45/00; A61K31/165; A61K31/167; A61K31/18; A61K31/343; A61K31/40; A61K31/506; A61P1/00; A61P3/10; A61P13/12; A61P17/00; A61P25/00; A61P27/02
Domestic Patent References:
| WO2021075536A1 | 2021-04-22 | |||
| WO2022181797A1 | 2022-09-01 |
Other References:
MIWAKO KASHI, ET AL: "O-11-4 Development of therapeutic method aiming at complete cure of diabetes by targeting bone marrow cells", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 20, no. Suppl., 26 February 2021 (2021-02-26) - 16 March 2021 (2021-03-16), JP , pages 220, XP009539553, ISSN: 1347-7919
BESANçON ALIX; GONCALVES TANIA; VALETTE FABRICE; DAHLLöF MATTIAS S.; MANDRUP-POULSEN THOMAS; CHATENOUD LUCIENNE; YOU SYL: "Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice", DIABETOLOGIA, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 61, no. 2, 13 October 2017 (2017-10-13), Berlin/Heidelberg, pages 389 - 398, XP036387771, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4459-0
S. M. CABRERA; S. C. COLVIN; S. A. TERSEY; B. MAIER; J. L. NADLER; R. G. MIRMIRA: "Effects of combination therapy with dipeptidyl peptidase‐IV and histone deacetylase inhibitors in the non‐obese diabetic mouse model of type 1 diabetes", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 172, no. 3, 18 April 2013 (2013-04-18), GB , pages 375 - 382, XP071081715, ISSN: 0009-9104, DOI: 10.1111/cei.12068
ARGUELLES ANDRIX O.; MERUVU SUNITHA; BOWMAN JOHN D.; CHOUDHURY MAHUA: "Are epigenetic drugs for diabetes and obesity at our door step?", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 3, 14 December 2015 (2015-12-14), AMSTERDAM, NL , pages 499 - 509, XP029464367, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2015.12.001
SHARMA SORABH; TALIYAN RAJEEV: "Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 113, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 320 - 326, XP029804511, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2016.09.009
"Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition)", 8 June 2018, ISBN: 978-0-12-812019-4, article LUÍS F. SCHÜTZ, MIN HI PARK, MAHUA CHOUDHURY: "Chapter 35 - HDACs in Diabetes: A New Era of Epigenetic Drug", pages: 475 - 486, XP009545780, DOI: 10.1016/B978-0-12-812019-4.00035-0
ERIKA F. BRUTSAERT: "Drug therapy for diabetes", MSD MANUAL PROFESSIONAL EDITION, MSD, JP, JP, pages 1 - 5, XP009546679, Retrieved from the Internet
M. LUNDH; D. P. CHRISTENSEN; M. DAMGAARD NIELSEN; S. J. RICHARDSON; M. S. DAHLLöF; T. SKOVGAARD; J. BERTHELSEN; C. A. DINARELLO; : "Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children", DIABETOLOGIA, SPRINGER, BERLIN, DE, vol. 55, no. 9, 7 July 2012 (2012-07-07), Berlin, DE , pages 2421 - 2431, XP035094596, ISSN: 1432-0428, DOI: 10.1007/s00125-012-2615-0
BESANçON ALIX; GONCALVES TANIA; VALETTE FABRICE; DAHLLöF MATTIAS S.; MANDRUP-POULSEN THOMAS; CHATENOUD LUCIENNE; YOU SYL: "Oral histone deacetylase inhibitor synergises with T cell targeted immunotherapy to preserve beta cell metabolic function and induce stable remission of new-onset autoimmune diabetes in NOD mice", DIABETOLOGIA, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 61, no. 2, 13 October 2017 (2017-10-13), Berlin/Heidelberg, pages 389 - 398, XP036387771, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4459-0
S. M. CABRERA; S. C. COLVIN; S. A. TERSEY; B. MAIER; J. L. NADLER; R. G. MIRMIRA: "Effects of combination therapy with dipeptidyl peptidase‐IV and histone deacetylase inhibitors in the non‐obese diabetic mouse model of type 1 diabetes", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 172, no. 3, 18 April 2013 (2013-04-18), GB , pages 375 - 382, XP071081715, ISSN: 0009-9104, DOI: 10.1111/cei.12068
ARGUELLES ANDRIX O.; MERUVU SUNITHA; BOWMAN JOHN D.; CHOUDHURY MAHUA: "Are epigenetic drugs for diabetes and obesity at our door step?", DRUG DISCOVERY TODAY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 3, 14 December 2015 (2015-12-14), AMSTERDAM, NL , pages 499 - 509, XP029464367, ISSN: 1359-6446, DOI: 10.1016/j.drudis.2015.12.001
SHARMA SORABH; TALIYAN RAJEEV: "Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes", PHARMACOLOGICAL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 113, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 320 - 326, XP029804511, ISSN: 1043-6618, DOI: 10.1016/j.phrs.2016.09.009
"Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (Second Edition)", 8 June 2018, ISBN: 978-0-12-812019-4, article LUÍS F. SCHÜTZ, MIN HI PARK, MAHUA CHOUDHURY: "Chapter 35 - HDACs in Diabetes: A New Era of Epigenetic Drug", pages: 475 - 486, XP009545780, DOI: 10.1016/B978-0-12-812019-4.00035-0
ERIKA F. BRUTSAERT: "Drug therapy for diabetes", MSD MANUAL PROFESSIONAL EDITION, MSD, JP, JP, pages 1 - 5, XP009546679, Retrieved from the Internet
M. LUNDH; D. P. CHRISTENSEN; M. DAMGAARD NIELSEN; S. J. RICHARDSON; M. S. DAHLLöF; T. SKOVGAARD; J. BERTHELSEN; C. A. DINARELLO; : "Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children", DIABETOLOGIA, SPRINGER, BERLIN, DE, vol. 55, no. 9, 7 July 2012 (2012-07-07), Berlin, DE , pages 2421 - 2431, XP035094596, ISSN: 1432-0428, DOI: 10.1007/s00125-012-2615-0
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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