Title:
METHOD FOR AMPLIFYING ERYTHROID PROGENITORS OR ERYTHROBLASTS, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/051685
Kind Code:
A1
Abstract:
A method for amplifying erythroid progenitors or erythroblasts and ultimately producing mature denucleated red blood cells, and an application thereof, specifically comprising using a BRAF kinase inhibitor, and a combination thereof with a TGF-β inhibitor and/or an SMAD2/3 inhibitor and/or a glucocorticoid and/or erythropoietin and/or stem cell factor.
Inventors:
LI XIANGYING (CN)
WU SHUNKANG (CN)
WU SHUNKANG (CN)
Application Number:
PCT/CN2022/122562
Publication Date:
April 06, 2023
Filing Date:
September 29, 2022
Export Citation:
Assignee:
UNIV BEIJING (CN)
International Classes:
A61K31/4439; A61P7/00
Domestic Patent References:
| WO2012149547A1 | 2012-11-01 |
Foreign References:
| CN113382717A | 2021-09-10 |
Other References:
CHUNG, S. S. ET AL.: "Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia.", SCIENCE TRANSLATIONAL MEDICINE., vol. 6, no. 238, 28 May 2014 (2014-05-28), XP055787671, DOI: 10.1126/scitranslmed.3008004
SURAGANI RAJASEKHAR NVS; MULIVOR AARON; PEARSALL R. SCOTT; KUMAR RAVINDRA: "RAP-536 Promotes Terminal Erythroid Differentiation and Reduces Anemia in Myelodysplastic Syndromes", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 118, no. 21, 18 November 2011 (2011-11-18), US , pages 610, XP086622970, ISSN: 0006-4971, DOI: 10.1182/blood.V118.21.610.610
ZHANG, HAOJIAN ET AL.: "TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia.", CELL STEM CELL., vol. 18, no. 5, 24 March 2016 (2016-03-24), XP029530850, DOI: 10.1016/j.stem.2016.03.002
HUI-FANG LI, YADONG CHEN, SHA-SHA RAO, XIU-MEI CHEN, HAI-CHUN LIU, JI-HONG QIN, WEI-FANG TANG, BENTHAM SCIENCE PUBLISHER YUE-WANG,: "Recent Advances in the Research and Development of B-Raf Inhibitors", CURRENT MEDICINAL CHEMISTRY, BENTHAM, NL, vol. 17, no. 16, 1 June 2010 (2010-06-01), NL , pages 1618 - 1634, XP055219752, ISSN: 0929-8673, DOI: 10.2174/092986710791111242
SIEBER, J. ET AL.: "GDC-0879, a BRAFV600E inhibitor, protects kidney podocytes from death.", CELL CHEMICAL BIOLOGY., vol. 25, no. 2, 14 December 2017 (2017-12-14)
SURAGANI RAJASEKHAR NVS; MULIVOR AARON; PEARSALL R. SCOTT; KUMAR RAVINDRA: "RAP-536 Promotes Terminal Erythroid Differentiation and Reduces Anemia in Myelodysplastic Syndromes", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 118, no. 21, 18 November 2011 (2011-11-18), US , pages 610, XP086622970, ISSN: 0006-4971, DOI: 10.1182/blood.V118.21.610.610
ZHANG, HAOJIAN ET AL.: "TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia.", CELL STEM CELL., vol. 18, no. 5, 24 March 2016 (2016-03-24), XP029530850, DOI: 10.1016/j.stem.2016.03.002
HUI-FANG LI, YADONG CHEN, SHA-SHA RAO, XIU-MEI CHEN, HAI-CHUN LIU, JI-HONG QIN, WEI-FANG TANG, BENTHAM SCIENCE PUBLISHER YUE-WANG,: "Recent Advances in the Research and Development of B-Raf Inhibitors", CURRENT MEDICINAL CHEMISTRY, BENTHAM, NL, vol. 17, no. 16, 1 June 2010 (2010-06-01), NL , pages 1618 - 1634, XP055219752, ISSN: 0929-8673, DOI: 10.2174/092986710791111242
SIEBER, J. ET AL.: "GDC-0879, a BRAFV600E inhibitor, protects kidney podocytes from death.", CELL CHEMICAL BIOLOGY., vol. 25, no. 2, 14 December 2017 (2017-12-14)
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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