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Title:
METHOD AND APPLICATION FOR BUILDING ANIMAL MODEL OF NON-HUMAN MAMMAL NEUROPSYCHIATRIC DISORDER
Document Type and Number:
WIPO Patent Application WO/2018/036490
Kind Code:
A1
Abstract:
A method for preparing an animal model of a non-human mammal neuropsychiatric disorder, the method comprising the following steps: (a) providing a non-human mammalian cell and inactivating the Glce gene in the cell to obtain a non-human mammalian cell having an inactive Glce gene; (b) using the non-human mammalian cell having an inactive Glce gene obtained in step (a) to prepare an animal model of a neuropsychiatric disorder having an inactive Glce gene. The animal model is an effective animal model of a neuropsychiatric disorder, which can be used to study neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, anxiety, phobia, autism spectrum disorders, stroke and Alzheimer's disease, and can be used for screening and testing certain drugs.

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Inventors:
DING KAN (CN)
LI YANLING (CN)
Application Number:
PCT/CN2017/098535
Publication Date:
March 01, 2018
Filing Date:
August 22, 2017
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
A61K49/00; A01K67/027; C12N5/10
Domestic Patent References:
WO2015123439A22015-08-20
Foreign References:
CN106282122A2017-01-04
CN106282123A2017-01-04
CN106344933A2017-01-25
CN106139165A2016-11-23
CN105112448A2015-12-02
CN103180445A2013-06-26
CN105283552A2016-01-27
CN1791416A2006-06-21
Other References:
LI, J.P . ET AL.: "Targeted Disruption of a Murine Glucuronyl C5-epimerase Gene Results in Heparan Sulfate Lacking L-Iduronic Acid and in Neonatal Lethality", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 31, 4 June 2003 (2003-06-04), pages 28363 - 28366, XP002638702
ZHU, LI ET AL.: "Function of Heparin Sulfate Proteoglycan on Nerve Regeneration after Injury", INTERNATIONAL JOURNAL OF STOMATOLOGY, vol. 40, no. 5, 30 September 2013 (2013-09-30), pages 687 - 690
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
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