Title:
METHOD FOR CATALYZED SYNTHESIS OF CHIRAL α-AMINOPHOSPHONIC ACID DERIVATIVE WITH CINCHONA ALKALOID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2024/008084
Kind Code:
A1
Abstract:
The present invention provides a method for catalyzed synthesis of a chiral α-aminophosphonic acid derivative with a cinchona alkaloid derivative. Particularly, the present invention provides a method for catalyzed synthesis of a chiral α-aminophosphonic acid derivative with a cinchona alkaloid derivative, comprising the following step: obtaining a chiral α-aminophosphonic acid derivative represented by formula III with an imine intermediate represented by formula II under the action of a cinchona alkaloid derivative catalyst.
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Inventors:
DENG LI (CN)
LU JIAXIANG (CN)
LU JIAXIANG (CN)
Application Number:
PCT/CN2023/105735
Publication Date:
January 11, 2024
Filing Date:
July 04, 2023
Export Citation:
Assignee:
UNIV WESTLAKE (CN)
International Classes:
C07B53/00; C07F9/40
Domestic Patent References:
| WO2023098759A1 | 2023-06-08 |
Foreign References:
| CN116199713A | 2023-06-02 |
Other References:
ZHOU, XIAO ET AL.: "Cinchonium Betaines as Efficient Catalysts for Asymmetric Proton Transfer Catalysis: The Development of a Practical Enantioselective Isomerization of Trifluoromethyl Imines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 37, 31 August 2016 (2016-08-31), pages 12297 - 12302, XP055433266, ISSN: 1520-5126, DOI: 10.1021/jacs.6b08727
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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