Title:
METHOD AND COMPOSITION FOR PREVENTING OR TREATING MYOPIA
Document Type and Number:
WIPO Patent Application WO/2023/210657
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for preventing or treating myopia, and a composition used in said method. The present invention provides a method and composition for inhibiting, improving, or treating myopia by administering a substance that induces M2 macrophage polarization, a substance that regulates the function of choroid-resident immune cells, such as a mast cell stabilizer or a chemical mediator release inhibitor, or lactic acid bacteria. Regulating the function of choroid-resident immune cells, for example by inducing the polarization of M2 macrophages in the choroid or by administering a mast cell stabilizer, a chemical mediator release inhibitor, or lactic acid bacteria, is effective in myopia prevention and treatment.
Inventors:
TSUBOTA KAZUO (JP)
KURIHARA TOSHIHIDE (JP)
IKEDA SHINICHI (JP)
HOU JING (JP)
KURIHARA TOSHIHIDE (JP)
IKEDA SHINICHI (JP)
HOU JING (JP)
Application Number:
PCT/JP2023/016344
Publication Date:
November 02, 2023
Filing Date:
April 25, 2023
Export Citation:
Assignee:
TSUBOTA LAB INC (JP)
International Classes:
A61K35/747; A23L33/18; A61K31/343; A61K31/366; A61K31/44; A61K31/4439; A61K31/496; A61K31/69; A61K31/7088; A61K38/02; A61K38/16; A61K38/20; A61K45/00; A61K48/00; A61P27/10; C07K14/54
Domestic Patent References:
| WO2018164113A1 | 2018-09-13 |
Foreign References:
| JPH07258083A | 1995-10-09 | |||
| US20210283087A1 | 2021-09-16 |
Other References:
SHOJI HITOSHI, HIROSHI TAKENAKA, KENJI DEJIMA: "Treatment for intractable perennial allergic rhinitis with AA-673 tablets", PLACTICA OTO-RHINO-LARYNGOLOGICA, vol. 82, no. 11, 1 January 1989 (1989-01-01), pages 1637 - 1648, XP093104777
ZHOU ZIXIONG; QI JING; LIM CHAE WOONG; KIM JONG-WON; KIM BUMSEOK: "Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro", TOXICOLOGY, LIMERICK, IR, vol. 444, 6 September 2020 (2020-09-06), IR , XP086284727, ISSN: 0300-483X, DOI: 10.1016/j.tox.2020.152579
FAN YUE, HUANG SI-LIN, LI HONG, CUI YU-LIN, LI DONG-YAN: "Resveratrol attenuates inflammation by regulating macrophage polarization via inhibition of toll-like receptor 4/MyD88 signaling pathway", PHARMACOGNOSY MAGAZINE, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., IN, vol. 17, no. 74, 1 January 2021 (2021-01-01), IN , pages 321, XP093104776, ISSN: 0973-1296, DOI: 10.4103/pm.pm_312_20
HAN GONG HO, KIM SEONG JUN, KO WAN‐KYU, LEE DAYE, HAN IN‐BO, SHEEN SEUNG HUN, HONG JE BEOM, SOHN SEIL: "Transplantation of tauroursodeoxycholic acid–inducing M2‐phenotype macrophages promotes an anti‐neuroinflammatory effect and functional recovery after spinal cord injury in rats", CELL PROLIFERATION, OXFORD., GB, vol. 54, no. 6, 1 June 2021 (2021-06-01), GB , XP093104773, ISSN: 0960-7722, DOI: 10.1111/cpr.13050
ZHOU ZIXIONG; QI JING; LIM CHAE WOONG; KIM JONG-WON; KIM BUMSEOK: "Dual TBK1/IKKε inhibitor amlexanox mitigates palmitic acid-induced hepatotoxicity and lipoapoptosis in vitro", TOXICOLOGY, LIMERICK, IR, vol. 444, 6 September 2020 (2020-09-06), IR , XP086284727, ISSN: 0300-483X, DOI: 10.1016/j.tox.2020.152579
FAN YUE, HUANG SI-LIN, LI HONG, CUI YU-LIN, LI DONG-YAN: "Resveratrol attenuates inflammation by regulating macrophage polarization via inhibition of toll-like receptor 4/MyD88 signaling pathway", PHARMACOGNOSY MAGAZINE, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD., IN, vol. 17, no. 74, 1 January 2021 (2021-01-01), IN , pages 321, XP093104776, ISSN: 0973-1296, DOI: 10.4103/pm.pm_312_20
HAN GONG HO, KIM SEONG JUN, KO WAN‐KYU, LEE DAYE, HAN IN‐BO, SHEEN SEUNG HUN, HONG JE BEOM, SOHN SEIL: "Transplantation of tauroursodeoxycholic acid–inducing M2‐phenotype macrophages promotes an anti‐neuroinflammatory effect and functional recovery after spinal cord injury in rats", CELL PROLIFERATION, OXFORD., GB, vol. 54, no. 6, 1 June 2021 (2021-06-01), GB , XP093104773, ISSN: 0960-7722, DOI: 10.1111/cpr.13050
Attorney, Agent or Firm:
WATANABE Shinichi (JP)
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