METHOD OF CRYSTALLIZING BICALUTAMIDE

Title:

METHOD OF CRYSTALLIZING BICALUTAMIDE

Document Type and Number:

WIPO Patent Application WO/2006/006736

Kind Code:

A1

Abstract:

A method of crystallizing bicalutamide, comprising adding an acetone solution containing bicalutamide to water. There is provided a crystal of bicalutamide obtained by the above method and having a particle size distribution of Dp₁₀=1 to 10 µm, Dp₅₀=10 to 25 µm and Dp₉₀=25 to 100 µm. Further, there is provided a crystal of bicalutamide having a particle size distribution of Dp₁₀=1 to 3 µm, Dp₅₀=2 to 5 µm and Dp₉₀=5 to 15 µm.

Inventors:

KATSURA TADASHI (JP)
MIZUNO TADASHI (JP)
ITAYA NOBUSHIGE (JP)

Application Number:

PCT/JP2005/013346

Publication Date:

January 19, 2006

Filing Date:

July 13, 2005

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Assignee:

SUMITOMO CHEMICAL CO (JP)
KATSURA TADASHI (JP)
MIZUNO TADASHI (JP)
ITAYA NOBUSHIGE (JP)

International Classes:

C07C315/06; C07C317/46; (IPC1-7): C07C315/06; C07C317/46

Domestic Patent References:

WO2004009057A1

2004-01-29

Foreign References:

US20040044249A1

2004-03-04

Other References: