Title:
METHOD FOR DEACTIVATING ACTIVATED STELLATE CELLS
Document Type and Number:
WIPO Patent Application WO/2023/223519
Kind Code:
A1
Abstract:
The present invention relates to a deactivating agent for activated hepatic stellate cells, said deactivating agent including a transforming proliferative factor β/bone morphogenetic protein signal inhibitor, an activin receptor-like kinase 3 inhibitor, and a Rho kinase inhibitor.
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Inventors:
MIYAJIMA ATSUSHI (JP)
KIDO TAKETOMO (JP)
NAKANO YASUHIRO (JP)
MIYATO MITSURU (JP)
KIDO TAKETOMO (JP)
NAKANO YASUHIRO (JP)
MIYATO MITSURU (JP)
Application Number:
PCT/JP2022/020894
Publication Date:
November 23, 2023
Filing Date:
May 19, 2022
Export Citation:
Assignee:
ISM CO LTD (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
C12N5/071
Domestic Patent References:
| WO2020166726A1 | 2020-08-20 |
Other References:
KOUI YUTA, HIMENO MISAO, MORI YUSUKE, NAKANO YASUHIRO, SAIJOU EIKO, TANIMIZU NAOKI, KAMIYA YOSHIKO, ANZAI HIROKO, MAEDA NATSUKI, W: "Development of human iPSC-derived quiescent hepatic stellate cell-like cells for drug discovery and in vitro disease modeling", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 16, no. 12, 1 December 2021 (2021-12-01), United States , pages 3050 - 3063, XP093109711, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2021.11.002
PESCHL VANESSA, SEITZ TATJANA, SOMMER JUDITH, THASLER WOLFGANG, BOSSERHOFF ANJA, HELLERBRAND CLAUS: "Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 123, no. 10, 1 October 2022 (2022-10-01), Hoboken, USA, pages 1544 - 1552, XP093109713, ISSN: 0730-2312, DOI: 10.1002/jcb.30248
WETTSTEIN GUILLAUME, LUCCARINI JEAN‐MICHEL, POEKES LAURENCE, FAYE PATRICK, KUPKOWSKI FRANCINE, ADARBES VANESSA, DEFRÊNE EVELYNE, E: "The new‐generation pan‐peroxisome proliferator‐activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis", HEPATOLOGY COMMUNICATIONS, vol. 1, no. 6, 1 August 2017 (2017-08-01), pages 524 - 537, XP093109722, ISSN: 2471-254X, DOI: 10.1002/hep4.1057
LEE TING FANG, MAK KI M., RACKOVSKY ORI, LIN YUN‐LIAN, KWONG ALLISON J., LOKE JOHNNY C., FRIEDMAN SCOTT L.: "Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation‐related protein (ADRP)", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 223, no. 3, 1 June 2010 (2010-06-01), US , pages 648 - 657, XP093109726, ISSN: 0021-9541, DOI: 10.1002/jcp.22063
PESCHL VANESSA, SEITZ TATJANA, SOMMER JUDITH, THASLER WOLFGANG, BOSSERHOFF ANJA, HELLERBRAND CLAUS: "Bone morphogenetic protein 13 in hepatic stellate cells and hepatic fibrosis", JOURNAL OF CELLULAR BIOCHEMISTRY, JOHN WILEY & SONS, INC. JOHN WILEY & SONS, INC., HOBOKEN, USA, vol. 123, no. 10, 1 October 2022 (2022-10-01), Hoboken, USA, pages 1544 - 1552, XP093109713, ISSN: 0730-2312, DOI: 10.1002/jcb.30248
WETTSTEIN GUILLAUME, LUCCARINI JEAN‐MICHEL, POEKES LAURENCE, FAYE PATRICK, KUPKOWSKI FRANCINE, ADARBES VANESSA, DEFRÊNE EVELYNE, E: "The new‐generation pan‐peroxisome proliferator‐activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis", HEPATOLOGY COMMUNICATIONS, vol. 1, no. 6, 1 August 2017 (2017-08-01), pages 524 - 537, XP093109722, ISSN: 2471-254X, DOI: 10.1002/hep4.1057
LEE TING FANG, MAK KI M., RACKOVSKY ORI, LIN YUN‐LIAN, KWONG ALLISON J., LOKE JOHNNY C., FRIEDMAN SCOTT L.: "Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation‐related protein (ADRP)", JOURNAL OF CELLULAR PHYSIOLOGY, WILEY SUBSCRIPTION SERVICES, INC., US, vol. 223, no. 3, 1 June 2010 (2010-06-01), US , pages 648 - 657, XP093109726, ISSN: 0021-9541, DOI: 10.1002/jcp.22063
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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