METHOD FOR DETECTING AND DETERMINING INTRAHEPATIC CHOLANGIOCARCINOMA

WIPO Patent Application WO/2010/100862

A1

Disclosed is a method for detecting and determining intrahepatic cholangiocarcinoma, which is a malignant tumor primarily occurring in the liver, in the early stage in a simple manner with high sensitivity and high reliability. Also disclosed is a kit for achieving the method. In the method, intrahepatic cholangiocarcinoma can be detected by detecting a cancer marker in a sample, wherein the cancer marker is a sugar chain biomarker comprising a lectin WFA (wisteria fioribunda agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma. The intrahepatic cholangiocarcinoma detection method enables the clear distinction of intrahepatic cholangiocarcinoma from hepatocellular carcinoma, and also enables the detection and determination of intrahepatic cholangiocarcinoma in the early stage with clinically acceptable applicability, sensitivity and accuracy.

KUNO ATSUSHI (JP)
HIRABAYASHI JUN (JP)
MATSUDA ATSUSHI (JP)
NARIMATSU HISASHI (JP)
IKEHARA YUZURU (JP)
SHODA JUNICHI (JP)
KAWAMOTO TORU (JP)

PCT/JP2010/001203

September 10, 2010

February 23, 2010

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NAT INST OF ADVANCED IND SCIEN (JP)
UNIV TSUKUBA (JP)
KUNO ATSUSHI (JP)
HIRABAYASHI JUN (JP)
MATSUDA ATSUSHI (JP)
NARIMATSU HISASHI (JP)
IKEHARA YUZURU (JP)
SHODA JUNICHI (JP)
KAWAMOTO TORU (JP)

G01N33/574; G01N21/64; G01N37/00

WO2005023301A1

2005-03-17

JP2003116580A	2003-04-22
JP2002323499A	2002-11-08
JPH08184594A	1996-07-16
JP2004105013A	2004-04-08
JP2005511023A	2005-04-28
JP2005526979A	2005-09-08
JP2005503176A	2005-02-03
JP2006094726A	2006-04-13
JP2007139742A	2007-06-07
JP2007506425A	2007-03-22
JP2007534722A	2007-11-29
JP2007322373A	2007-12-13
JP2007278803A	2007-10-25
JP2003527583A	2003-09-16
JP2005304497A	2005-11-04
JP2008072952A	2008-04-03

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See also references of EP 2405269A4

HIROTA, Masanori (JP)
Masaki Hirota (JP)

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