Title:
METHOD FOR DETECTING T-CELL LYMPHOMA
Document Type and Number:
WIPO Patent Application WO/2014/178432
Kind Code:
A1
Abstract:
A method for detecting T-cell lymphoma characterized in that gene mutations of at least one base selected from a group comprising base numbers 50, 331, 334, and 482 or gene mutations of base numbers 49 to 51 in the base sequence of an RHOA gene collected from a subject are analyzed, and the analysis results and T-cell lymphoma are associated with each other.
Inventors:
CHIBA SHIGERU (JP)
YANAGIMOTO MAMIKO (JP)
OGAWA SEISHI (JP)
YANAGIMOTO MAMIKO (JP)
OGAWA SEISHI (JP)
Application Number:
PCT/JP2014/062112
Publication Date:
November 06, 2014
Filing Date:
May 01, 2014
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
C12N15/09; C12Q1/68
Other References:
DE LEVAL L. ET AL.: "The gene expression profile of nodal peripheral T- cell lymphoma demonstrates a molecular link between angioimmunoblastic T- cell lymphoma (AITL) and follicular helper T (TFH) cells.", BLOOD, vol. 109, no. 11, 2007, pages 4952 - 4963
LEMONNIER F. ET AL.: "Recurrent TET2 mutations in peripheral T- cell lymphomas correlate with TFH-like features and adverse clinical parameters.", BLOOD, vol. 120, no. 7, 2012, pages 1466 - 1469
COURONNÉ L. ET AL.: "TET2 and DNMT3A mutations in human T- cell lymphoma.", N. ENGL. J. MED., vol. 366, no. 1, 2012, pages 95 - 96
DATABASE NCBI 2 August 1999 (1999-08-02), "Homo sapiens GTP-binding protein (rhoA) mRNA", retrieved from http://www. ncbi.nlm.nih.gov/nuccore/L25080 accession no. 25080 (GI:407696
SAKATA-Y. M. ET AL.: "Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.", NAT. GENET., vol. 46, no. 2, February 2014 (2014-02-01), pages 171 - 175
LEMONNIER F. ET AL.: "Recurrent TET2 mutations in peripheral T- cell lymphomas correlate with TFH-like features and adverse clinical parameters.", BLOOD, vol. 120, no. 7, 2012, pages 1466 - 1469
COURONNÉ L. ET AL.: "TET2 and DNMT3A mutations in human T- cell lymphoma.", N. ENGL. J. MED., vol. 366, no. 1, 2012, pages 95 - 96
DATABASE NCBI 2 August 1999 (1999-08-02), "Homo sapiens GTP-binding protein (rhoA) mRNA", retrieved from http://www. ncbi.nlm.nih.gov/nuccore/L25080 accession no. 25080 (GI:407696
SAKATA-Y. M. ET AL.: "Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.", NAT. GENET., vol. 46, no. 2, February 2014 (2014-02-01), pages 171 - 175
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (JP)
Kobayashi 浩 (JP)
Kobayashi 浩 (JP)
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