Title:
METHOD FOR DETERMINING OCCURRENCE OF AFFECTION WITH INVASIVE ADENOCARCINOMA, METHOD FOR ANALYSIS ON SAID AFFECTION, AND MARKER GLYCOPROTEIN FOR USE IN THESE METHODS AND FRAGMENT THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/241801
Kind Code:
A1
Abstract:
A marker glycoprotein according to an embodiment is a marker glycoprotein for determining as to whether or not the type of adenocarcinoma affecting a subject is invasive adenocarcinoma as distinguished from preinvasive lesion or microinvasive carcinoma. The marker glycoprotein comprises a protein and a sugar chain bonded to the protein. The protein is PLOD3 or CP, and the sugar chain is capable of binding to HHL.
Inventors:
TOGAYACHI AKIRA (JP)
KUNO ATSUSHI (JP)
KAJI HIROYUKI (JP)
NARIMATSU HISASHI (JP)
NOGUCHI MASAYUKI (JP)
MATSUOKA RYOTA (JP)
IKEDA NORIHIKO (JP)
NAGAO TOSHITAKA (JP)
MAEDA JUNICHI (JP)
SAKURAI YASUO (JP)
YOSHIMURA SEIKO (JP)
KANAYAMA SHOICHI (JP)
KUNO ATSUSHI (JP)
KAJI HIROYUKI (JP)
NARIMATSU HISASHI (JP)
NOGUCHI MASAYUKI (JP)
MATSUOKA RYOTA (JP)
IKEDA NORIHIKO (JP)
NAGAO TOSHITAKA (JP)
MAEDA JUNICHI (JP)
SAKURAI YASUO (JP)
YOSHIMURA SEIKO (JP)
KANAYAMA SHOICHI (JP)
Application Number:
PCT/JP2020/021244
Publication Date:
December 03, 2020
Filing Date:
May 28, 2020
Export Citation:
Assignee:
AIST (JP)
UNIV TSUKUBA (JP)
UNIV TOKYO MEDICAL (JP)
CANON MEDICAL SYSTEMS CORP (JP)
UNIV TSUKUBA (JP)
UNIV TOKYO MEDICAL (JP)
CANON MEDICAL SYSTEMS CORP (JP)
International Classes:
C12N15/53; C12N9/02; C12Q1/6886; G01N33/574
Foreign References:
| US20150147765A1 | 2015-05-28 | |||
| JP2015105951A | 2015-06-08 |
Other References:
XIAONING WANG, ZAIAN DENG, CHUNCUI HUANG, TONG ZHU, JIATAO LOU, LIN WANG, YAN LIAB: "Differential N-glycan patterns identified in lung adenocarcinoma by N-glycan profiling of formalin-fixed paraffin-embedded (FFPE) tissue sections", JOURNAL OF PROTEOMICS, vol. 172, 2018, pages 1 - 10, XP055769406
YEONG HEE AHN, EUN SUN JI , NA REE OH , YONG-SAM KIM , JEONG HEON KO , JONG SHIN YOO: "Differential proteomic approach for identification and verification of aberrantly glycosylated proteins in adenocarcinoma lung cancer (ADLC) plasmas by lectin-capturing and targeted mass spectrometry", JOURNAL OF PROTEOMICS, vol. 106, 2014, pages 221 - 229, XP055769409
HIRAO, Y. ET AL.: "Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma", JOURNAL OF PROTEOME RESEARCH, vol. 13, no. 11, 2014, pages 4705 - 4716, XP055528619, DOI: 10.1021/pr5006668
HAIDI YIN, ZHENXIN LIN, SONG NIE, JING WU, ZHIJING TAN, JIANHUI ZHU, JIANLIANG DAI, ZIDING FENG, JORGE MARRERO, DAVID M. LUBMAN: "Mass-Selected Site-Specific Core-Fucosylation of Ceruloplasmin in Alcohol-Related Hepatocellular Carcinoma", JOURNAL OF PROTEOME RESEARCH, vol. 13, no. 6, 2014, pages 2887 - 2896, XP055769410
SHEN, Q. ET AL.: "Barrier to Autointegration Factor 1, Procollagen-Lysine, 2-0xoglutarate 5-Dioxygenase 3, and Splicing Factor 3b Subunit 4 as Early- Stage Cancer Decision Markers and Drivers of Hepatocellular Carcinoma", HEPATOLOGY, vol. 67, no. 4, 2018, pages 1360 - 1377, XP055630132, DOI: 10.1002/hep.29606
YEONG HEE AHN, EUN SUN JI , NA REE OH , YONG-SAM KIM , JEONG HEON KO , JONG SHIN YOO: "Differential proteomic approach for identification and verification of aberrantly glycosylated proteins in adenocarcinoma lung cancer (ADLC) plasmas by lectin-capturing and targeted mass spectrometry", JOURNAL OF PROTEOMICS, vol. 106, 2014, pages 221 - 229, XP055769409
HIRAO, Y. ET AL.: "Glycoproteomics Approach for Identifying Glycobiomarker Candidate Molecules for Tissue Type Classification of Non-small Cell Lung Carcinoma", JOURNAL OF PROTEOME RESEARCH, vol. 13, no. 11, 2014, pages 4705 - 4716, XP055528619, DOI: 10.1021/pr5006668
HAIDI YIN, ZHENXIN LIN, SONG NIE, JING WU, ZHIJING TAN, JIANHUI ZHU, JIANLIANG DAI, ZIDING FENG, JORGE MARRERO, DAVID M. LUBMAN: "Mass-Selected Site-Specific Core-Fucosylation of Ceruloplasmin in Alcohol-Related Hepatocellular Carcinoma", JOURNAL OF PROTEOME RESEARCH, vol. 13, no. 6, 2014, pages 2887 - 2896, XP055769410
SHEN, Q. ET AL.: "Barrier to Autointegration Factor 1, Procollagen-Lysine, 2-0xoglutarate 5-Dioxygenase 3, and Splicing Factor 3b Subunit 4 as Early- Stage Cancer Decision Markers and Drivers of Hepatocellular Carcinoma", HEPATOLOGY, vol. 67, no. 4, 2018, pages 1360 - 1377, XP055630132, DOI: 10.1002/hep.29606
Attorney, Agent or Firm:
S & S INTERNATIONAL PPC (JP)
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