Title:
METHOD FOR DETERMINING VASCULAR DISORDER
Document Type and Number:
WIPO Patent Application WO/2020/017589
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for determining a vascular disorder by identifying a vascular disorder marker at a clinically practical level. According to the present invention, a method for determining a vascular disorder can be provided, which comprises measuring the amount of S-(2-succinyl)cysteine in blood.
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Inventors:
NAGAI RYOJI (JP)
MATSUMURA TAKESHI (JP)
MATSUMURA TAKESHI (JP)
Application Number:
PCT/JP2019/028260
Publication Date:
January 23, 2020
Filing Date:
July 18, 2019
Export Citation:
Assignee:
TOKAI UNIV EDUCATIONAL SYSTEM (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
G01N33/53; G01N27/62; G01N33/15; G01N33/50; G01N33/68
Foreign References:
| JP2017049024A | 2017-03-09 | |||
| JP2014119370A | 2014-06-30 |
Other References:
SHINAGAWA, MASATOSHI ET AL.: "Measurement of 2SC using immunological and analytical chemistry techniques", PROGRAMS AND ABSTRACTS OF THE 67TH ANNUAL MEETING OF SOCIETY FOR FREE RADICAL RESEARCH JAPAN, 29 August 2014 (2014-08-29), pages 92
ICHIMARU, K ET AL.: "Detection of S- (2-succinyl) cystein (2SC) by LC-MS/MS as a marker for mitochondrial dysfunctions", vol. 1 6, 2016, pages 66
THOMAS, S. A. ET AL.: "Tissue Distribution of S-(2-Succino)cysteine (2SC) , a Biomarker of Mitochondrial Stress in Obesity and Diabetes", OBESITY, vol. 20, no. 2, 6 September 2012 (2012-09-06), pages 263 - 269
BENNETT, J. A. ET AL.: "Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases", MODERN PATHOLOGY, vol. 30, 30 June 2017 (2017-06-30), pages 1476 - 1488, XP055676461
BLATNIK, M. ET AL.: "Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes", DIABETES, vol. 57, no. 1, 12 October 2007 (2007-10-12), pages 41 - 49, XP055676459
NAGAI, R. ET AL.: "Succination of Protein Thiols during Adipocyte Maturation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 47, 23 November 2007 (2007-11-23), pages 34219 - 34228, XP055676458
ICHIMARU, K ET AL.: "Detection of S- (2-succinyl) cystein (2SC) by LC-MS/MS as a marker for mitochondrial dysfunctions", vol. 1 6, 2016, pages 66
THOMAS, S. A. ET AL.: "Tissue Distribution of S-(2-Succino)cysteine (2SC) , a Biomarker of Mitochondrial Stress in Obesity and Diabetes", OBESITY, vol. 20, no. 2, 6 September 2012 (2012-09-06), pages 263 - 269
BENNETT, J. A. ET AL.: "Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases", MODERN PATHOLOGY, vol. 30, 30 June 2017 (2017-06-30), pages 1476 - 1488, XP055676461
BLATNIK, M. ET AL.: "Inactivation of Glyceraldehyde-3-Phosphate Dehydrogenase by Fumarate in Diabetes", DIABETES, vol. 57, no. 1, 12 October 2007 (2007-10-12), pages 41 - 49, XP055676459
NAGAI, R. ET AL.: "Succination of Protein Thiols during Adipocyte Maturation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 47, 23 November 2007 (2007-11-23), pages 34219 - 34228, XP055676458
Attorney, Agent or Firm:
SIKS & CO. (JP)
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