Title:
METHOD AND DEVICE FOR DIRECTED SORT COMBINATIONAL SYNTHESIS
Document Type and Number:
WIPO Patent Application WO2003009940
Kind Code:
A3
Abstract:
A sorting apparatus and method for directed sort combinatorial chemical synthesis is provided. This invention relates to a directed flexible, sorting apparatus and method for combinatorial chemical synthesis using a directed split and recombine process. The process utilizes one algorithm that is universal in directing and sorting a library of any size. This invention further provides a method of sorting solid supports for combinatorial chemical synthesis comprising delivering one or more supports which are organized in a one dimensional linear array in one or more reaction vessels, to an isolation and transfer chamber, transferring one or more support from each of said reaction vessels to one or more subsequent reaction vessels, in a patterned distribution; wherein the patterned distribution of supports in each subsequent transfer is identical and the position of each support in a reaction vessel codes for its previous synthesis history. In another aspect, the invention provides a directed sort apparatus wherein all members of a set at a given point in time are reacted with the same chemical building blocks throughout synthesis.
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Inventors:
KRCHNAK VIKTOR (US)
VAGNER JOSEF (US)
SELIGMANN BRUCE A (US)
VAGNER JOSEF (US)
SELIGMANN BRUCE A (US)
Application Number:
PCT/US2002/023489
Publication Date:
October 30, 2003
Filing Date:
July 24, 2002
Export Citation:
Assignee:
HIGH THROUGHPUT GENOMICS INC (US)
KRCHNAK VIKTOR (US)
VAGNER JOSEF (US)
SELIGMANN BRUCE A (US)
KRCHNAK VIKTOR (US)
VAGNER JOSEF (US)
SELIGMANN BRUCE A (US)
International Classes:
B01J19/00; C07B61/00; B01L3/00; B01L3/02; (IPC1-7): G01N31/00
Foreign References:
| US5565324A | 1996-10-15 | |||
| US5968736A | 1999-10-19 | |||
| US6001579A | 1999-12-14 |
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