Title:
METHOD FOR DIAGNOSING LIVER DISEASE VIA BACTERIAL METAGENOMIC ANALYSIS
Document Type and Number:
WIPO Patent Application WO/2018/124744
Kind Code:
A1
Abstract:
The present invention relates to a method for diagnosing a liver disease, such as liver cancer and cirrhosis, via bacterial metagenomic analysis and, more particularly, to a method for diagnosing liver cancer and cirrhosis by performing bacterial metagenomic analysis using a subject-derived sample, and by analyzing an increase or decrease in the content of a specific bacterium-derived extracellular vesicle. An extracellular vesicle secreted from a bacterium present in the environment can be absorbed into the body and directly affect the occurrence of inflammation and cancer, and a liver disease, such as liver cancer and cirrhosis, is difficult to diagnose early on before any symptom appears, which makes efficient treatment difficult. As such, through the metagenomic analysis on a gene present in a bacterium-derived extracellular vesicle using a human body-derived sample according to the present invention, the risk of the onset of liver cancer and cirrhosis can be predicted in advance, enabling early diagnosis and prediction of a liver disease risk group and delay of the time of the onset or prevention of the onset through proper care, and early diagnosis is still possible even after the onset of cirrhosis or liver cancer, which can lower the incidence rate of the liver disease and enhance the treatment effect.
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Inventors:
KIM YOON-KEUN (KR)
PARK TAESUNG (KR)
YOON JUNG-HWAN (KR)
LEEM SANGSEOB (KR)
PARK TAESUNG (KR)
YOON JUNG-HWAN (KR)
LEEM SANGSEOB (KR)
Application Number:
PCT/KR2017/015578
Publication Date:
July 05, 2018
Filing Date:
December 27, 2017
Export Citation:
Assignee:
MD HEALTHCARE INC (KR)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2016099076A1 | 2016-06-23 |
Foreign References:
| KR20110025603A | 2011-03-10 | |||
| US20130121968A1 | 2013-05-16 | |||
| KR20160110232A | 2016-09-21 |
Other References:
EZZAT, ASMAA ET AL.: "Metagenomic Study of the Liver Microbiota in Liver Cancer-metagenomic and Metatranscriptomic Analyses of the Hepatocellular Carcinoma- associated Microbial Communities and the Potential Role of Microbial Communities in Liver Cancer", JOURNAL OF GASTROINTESTINAL & DIGESTIVE SYSTEM, vol. 4, no. 5, 2014, pages 1 - 10, XP055516508
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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