Title:
METHOD OF DIFFERENTIATING INSULIN-PRODUCING CELLS USING IONIZED ATELOCOLLAGEN, AND ARTIFICIAL PANCREAS MANUFACTURED USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/149649
Kind Code:
A1
Abstract:
The present invention relates to a method of differentiating insulin-producing cells by using ionized atelocollagen, and to an artificial pancreas manufactured using same. As it was found that the use of a hydrogel containing ionized atelocollagen in a method of inducing sequential differentiations of human induced pluripotent stem cells (iPSC) to definitive endoderm, pancreatic progenitor cells, and pancreatic endocrine cells, results in the production of insulin-producing cells with a more mature differentiation level compared to a two-dimensional culture, the present invention provides a method of inducing differentiation of insulin-producing cells by using a hydrogel containing ionized atelocollagen, and insulin-producing cells and an artificial pancreas produced thereby.
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Inventors:
KIM SONG-CHEOL (KR)
SHIM INKYONG (KR)
LEE YUNA (KR)
SHIM INKYONG (KR)
LEE YUNA (KR)
Application Number:
PCT/KR2021/001527
Publication Date:
July 14, 2022
Filing Date:
February 05, 2021
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C12N5/071; C12M1/32; C12M3/00; C12N11/08
Domestic Patent References:
| WO2014044646A1 | 2014-03-27 |
Foreign References:
| KR20200049669A | 2020-05-08 | |||
| KR20150067945A | 2015-06-19 |
Other References:
ZUJUR DENISE, KANKE KOSUKE, LICHTLER ALEXANDER C., HOJO HIRONORI, CHUNG UNG-IL, OHBA SHINSUKE: "Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions", SCIENCE ADVANCES, vol. 3, no. 5, 12 May 2017 (2017-05-12), pages 1 - 10, XP055950143, DOI: 10.1126/sciadv.1602875
S. KUMAR, ABDULLAH ALARFAJ, MURUGAN MUNUSAMY, A. SINGH, I-CHIA PENG, SIVAN PRIYA, RUKMAN HAMAT, AKON HIGUCHI: "Recent Developments in β-Cell Differentiation of Pluripotent Stem Cells Induced by Small and Large Molecules", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 15, no. 12, 1 January 2014 (2014-01-01) - 17 December 2014 (2014-12-17), pages 23418 - 23447, XP055167269, DOI: 10.3390/ijms151223418
KIM SEON AE, SUR YOO JOON, CHO MI-LA, GO EUN JEONG, KIM YUN HWAN, SHETTY ASODE ANANTHRAM, KIM SEOK JUNG: "Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), pages 1 - 18, XP055950148, DOI: 10.1038/s41598-020-67836-3
S. KUMAR, ABDULLAH ALARFAJ, MURUGAN MUNUSAMY, A. SINGH, I-CHIA PENG, SIVAN PRIYA, RUKMAN HAMAT, AKON HIGUCHI: "Recent Developments in β-Cell Differentiation of Pluripotent Stem Cells Induced by Small and Large Molecules", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 15, no. 12, 1 January 2014 (2014-01-01) - 17 December 2014 (2014-12-17), pages 23418 - 23447, XP055167269, DOI: 10.3390/ijms151223418
KIM SEON AE, SUR YOO JOON, CHO MI-LA, GO EUN JEONG, KIM YUN HWAN, SHETTY ASODE ANANTHRAM, KIM SEOK JUNG: "Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells", SCIENTIFIC REPORTS, vol. 10, no. 1, 1 December 2020 (2020-12-01), pages 1 - 18, XP055950148, DOI: 10.1038/s41598-020-67836-3
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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