Title:
METHOD FOR DIRECTLY DETECTING PATHOGENIC STRAIN HAVING RESISTANCE TO BETA-LACTAM ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2021/025413
Kind Code:
A1
Abstract:
The present invention relates to a method for detecting a pathogenic strain having resistance to β-lactam antibiotics in a biological sample, and a method for identifying a β-lactam antibiotic resistance-related protein contained in a biological sample. The present invention can quickly and accurately determine whether a pathogenic strain is resistant to antibiotics, as well as the type of resistance-related proteins, by directly identifying an extended spectrum β-lactamase (ESBL) protein with a truncated N-terminus through mass spectrometry. Accordingly, the present invention can be effectively utilized to quickly establish an appropriate antibiotic administration strategy at the initial stage of infection.
Inventors:
CHUN JONG KEE (KR)
BAEK JE HYUN (KR)
YANG WON SUK (KR)
LEE SAEYOUNG (KR)
BAEK JE HYUN (KR)
YANG WON SUK (KR)
LEE SAEYOUNG (KR)
Application Number:
PCT/KR2020/010228
Publication Date:
February 11, 2021
Filing Date:
August 03, 2020
Export Citation:
Assignee:
SEEGENE MEDICAL FOUND (KR)
International Classes:
G01N33/68; B01D15/36; G01N30/88; G01N30/96
Foreign References:
| EP2816357A1 | 2014-12-24 | |||
| US20120196309A1 | 2012-08-02 | |||
| KR20160091602A | 2016-08-03 | |||
| US20130244230A1 | 2013-09-19 |
Other References:
TADROS MANAL, GONEAU LEE, ROMASCHIN ALEXANDER, JARVIS MICHAEL, MATUKAS LARISSA: "Rapid detection of resistance to carbapenems and cephalosporins in Enterobacteriaceae using liquid chromatography tandem mass spectrometry", PLOS ONE, vol. 13, no. 11, e0206842, 9 November 2018 (2018-11-09), pages 1 - 10, XP055778265, DOI: 10.1371/journal.pone.0206842
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
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