Title:
METHOD FOR ESTIMATING BREAST CANCER CELL ABUNDANCE
Document Type and Number:
WIPO Patent Application WO/2020/054782
Kind Code:
A1
Abstract:
The present invention provides improved accuracy of an index for estimating the efficacy of drug therapy for breast cancer. Specifically, provided is a method for estimating breast cancer cell abundance, the method comprising the following (1) and (2): (1) analyzing, in an human subject-derived sample, a methylation rate of: (a) a cytosine residue in a CG region comprising 1000th and 1001st nucleotides in a nucleotide sequence expressed by SEQ ID NO: 1; (b) a cytosine residue in a CG region comprising 1000th and 1001st nucleotides in a nucleotide sequence expressed by SEQ ID NO: 2; (c) a cytosine residue in a CG region comprising 1001st and 1002nd nucleotides in a nucleotide sequence expressed by SEQ ID NO: 3; or (d) a combination thereof; and (2) estimating, on the basis of the analyzed methylation rate, the breast cancer abundance in the human subject-derived sample.
Inventors:
ISHIHARA HIROKI (JP)
USHIJIMA TOSHIKAZU (JP)
USHIJIMA TOSHIKAZU (JP)
Application Number:
PCT/JP2019/035774
Publication Date:
March 19, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
NAT CANCER CT (JP)
MIRACA RES INSTITUTE G K (JP)
MIRACA RES INSTITUTE G K (JP)
International Classes:
C12Q1/6869; A61P15/00; A61P35/00; G01N33/50; G01N33/53; G01N33/574; A61K45/00; C12N15/12
Domestic Patent References:
| WO2009136501A1 | 2009-11-12 | |||
| WO2015025862A1 | 2015-02-26 | |||
| WO2015025863A1 | 2015-02-26 | |||
| WO2015025864A1 | 2015-02-26 | |||
| WO2016052368A1 | 2016-04-07 |
Foreign References:
| JP2012090555A | 2012-05-17 | |||
| JP2014036672A | 2014-02-27 | |||
| JP2010538638W | ||||
| JP2012230019A | 2012-11-22 |
Other References:
MIYAMOTO, KAZUAKI ET AL.: "Identification of 20 genes aberrantly methylated in human breast cancers", INT. J. CANCER, vol. 116, no. 3, September 2005 (2005-09-01), pages 407 - 414, XP002711967, DOI: 10.1002/IJC.21054
DEDEURWAERDER, S.: "DNA methylation profiling reveals a predominant immune component in breast cancers", EMBO MOL. MED., vol. 3, no. 12, December 2011 (2011-12-01), pages 726 - 741, XP055026119, DOI: 10.1002/emmm.201100801
DING, S. ET AL.: "Methylation profile of the promoter CpG island s of 14 ''drug-resistance'' genes in hepatocellular carcinoma", WORLD J GASTROENTEROLOGY, vol. 10, no. 23, 1 December 2004 (2004-12-01), pages 3433 - 3440, XP055694085
FUJII SYAMASHITA SYAMAGUCHI TTAKAHASHI MHOZUMI YUSHIJIMA T ET AL.: "Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation", ONCOTARGET, vol. 8, no. 12, 2017, pages 19039 - 48, XP055462043, DOI: 10.18632/oncotarget.15118
TAKAHASHI T ET AL., PLOS ONE, vol. 8, no. 12, 2013, pages e82302
ZONG L ET AL., GASTRIC CANCER, vol. 19, no. 2, 2016, pages 361 - 9
DNA RESEARCH, vol. 13, 2006, pages 37 - 42
ANAL. CHEM., vol. 84, 2012, pages 7533 - 7538
COUSSENS ET AL., SCIENCE, vol. 230, no. 4730, 1985, pages 1132 - 1139
"Genebank", Database accession no. NP 001005862.1
YAMASHITA STAKAHASHI SMCDONELL NWATANABE NNIWA THOSOYA K ET AL.: "Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers", CANCER RESEARCH, vol. 68, no. 7, 2008, pages 2112 - 21, XP055080616, DOI: 10.1158/0008-5472.CAN-07-5282
YOSHIDA TYAMASHITA STAKAMURA-ENYA TNIWA TANDO TENOMOTO S ET AL.: "Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae", INTERNATIONAL JOURNAL OF CANCER, vol. 128, no. 1, 2011, pages 33 - 9
See also references of EP 3851543A4
DEDEURWAERDER, S.: "DNA methylation profiling reveals a predominant immune component in breast cancers", EMBO MOL. MED., vol. 3, no. 12, December 2011 (2011-12-01), pages 726 - 741, XP055026119, DOI: 10.1002/emmm.201100801
DING, S. ET AL.: "Methylation profile of the promoter CpG island s of 14 ''drug-resistance'' genes in hepatocellular carcinoma", WORLD J GASTROENTEROLOGY, vol. 10, no. 23, 1 December 2004 (2004-12-01), pages 3433 - 3440, XP055694085
FUJII SYAMASHITA SYAMAGUCHI TTAKAHASHI MHOZUMI YUSHIJIMA T ET AL.: "Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation", ONCOTARGET, vol. 8, no. 12, 2017, pages 19039 - 48, XP055462043, DOI: 10.18632/oncotarget.15118
TAKAHASHI T ET AL., PLOS ONE, vol. 8, no. 12, 2013, pages e82302
ZONG L ET AL., GASTRIC CANCER, vol. 19, no. 2, 2016, pages 361 - 9
DNA RESEARCH, vol. 13, 2006, pages 37 - 42
ANAL. CHEM., vol. 84, 2012, pages 7533 - 7538
COUSSENS ET AL., SCIENCE, vol. 230, no. 4730, 1985, pages 1132 - 1139
"Genebank", Database accession no. NP 001005862.1
YAMASHITA STAKAHASHI SMCDONELL NWATANABE NNIWA THOSOYA K ET AL.: "Methylation silencing of transforming growth factor-beta receptor type II in rat prostate cancers", CANCER RESEARCH, vol. 68, no. 7, 2008, pages 2112 - 21, XP055080616, DOI: 10.1158/0008-5472.CAN-07-5282
YOSHIDA TYAMASHITA STAKAMURA-ENYA TNIWA TANDO TENOMOTO S ET AL.: "Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae", INTERNATIONAL JOURNAL OF CANCER, vol. 128, no. 1, 2011, pages 33 - 9
See also references of EP 3851543A4
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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