Title:
METHOD FOR EVALUATING DRUG TOXICITY
Document Type and Number:
WIPO Patent Application WO/2021/075528
Kind Code:
A1
Abstract:
The present invention provides a drug toxicity evaluation platform (evaluation method and kit therefor, etc.) that makes it possible to perform a detailed analysis of the likelihood that a drug will cause injury (DILI, etc.) to the liver or another organ. This method for evaluating drug toxicity includes a step for adding a drug to a co-culture of an organoid and blood cells, and a step for evaluating the toxicity of said drug to said organoid.
Inventors:
TAKEBE TAKANORI (JP)
SAIKI NORIKAZU (JP)
SAIKI NORIKAZU (JP)
Application Number:
PCT/JP2020/039023
Publication Date:
April 22, 2021
Filing Date:
October 16, 2020
Export Citation:
Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
TAKEDA PHARMACEUTICALS CO (JP)
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C12N5/071; C12N5/078; C12Q1/02
Domestic Patent References:
| WO2019122388A1 | 2019-06-27 | |||
| WO2018035138A1 | 2018-02-22 | |||
| WO2018218344A1 | 2018-12-06 | |||
| WO2015129822A1 | 2015-09-03 |
Foreign References:
| JP2019517808A | 2019-06-27 | |||
| JP2019516384A | 2019-06-20 | |||
| JP2016202032A | 2016-12-08 | |||
| JP2019129707A | 2019-08-08 | |||
| US20120301892A1 | 2012-11-29 | |||
| JP2016202032A | 2016-12-08 | |||
| JPH0216255B2 | 1990-04-16 | |||
| JP2018110575A | 2018-07-19 |
Other References:
DEVI, K. ET AL.: "Assessing the immunomodulatory role of heteroglycan in a tumor spheroid and macrophage co-culture model system", CARBOHYDRATE POLYMERS, vol. 127, 25 March 2015 (2015-03-25), pages 1 - 10, XP029158987, DOI: 10.1016/j.carbpol.2015.03.035
COURAU, TRISTAN ET AL.: "Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 7, no. 1, 14 March 2019 (2019-03-14), pages 1 - 14, XP002795053, [retrieved on 20201104], DOI: https://doi.org/10.1186/s40425-019-0553-9
A. GRANITZNY ET AL., TOXICOLOGY REPORTS, vol. 4, 2017, pages 89 - 103
K. SI-TAIYEB ET AL., HEPATOLOGY, vol. 51, no. 1, 2010, pages 1754 - 305
CELL REP., vol. 21, no. 10, 2017, pages 2661 - 2670
N ENGL J MED, vol. 381, 2019, pages 264 - 273
See also references of EP 4047082A4
COURAU, TRISTAN ET AL.: "Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment", JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 7, no. 1, 14 March 2019 (2019-03-14), pages 1 - 14, XP002795053, [retrieved on 20201104], DOI: https://doi.org/10.1186/s40425-019-0553-9
A. GRANITZNY ET AL., TOXICOLOGY REPORTS, vol. 4, 2017, pages 89 - 103
K. SI-TAIYEB ET AL., HEPATOLOGY, vol. 51, no. 1, 2010, pages 1754 - 305
CELL REP., vol. 21, no. 10, 2017, pages 2661 - 2670
N ENGL J MED, vol. 381, 2019, pages 264 - 273
See also references of EP 4047082A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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