Title:
METHOD OF FUNGUS CULTURING
Document Type and Number:
WIPO Patent Application WO/2006/028048
Kind Code:
A1
Abstract:
A method of microbe culturing, in which a microbe capable of producing at least either a highly unsaturated fatty acid or a compound containing a highly unsaturated fatty acid as a constituent fatty acid is cultured in a culture medium containing at least a carbon source and a nitrogen source by means of an aerated spinner culturing apparatus capable of regulation and control of agitation power and aeration rate. In particular, there is provided a method of fungus culturing wherein while a mechanical agitation of ≤ 269 W/m3 agitation power per liquid quantity is performed for a given period of time from culturing initiation, at least either the maximum aeration rate or the maximum agitation power required is regulated and controlled after the passage of the given period of time within such a range as to satisfy the relationships of, when P refers to agitation power required (W), V to liquid quantity (m3) and Vs to aeration linear velocity (m/sec), KLA(=(P/V)0.95Vs0.67) ≥ 59, aeration linear velocity parameter Vs0.67 ≥ 0.075 and agitation power requirement parameter (P/V)0.95 ≥ 203.
Inventors:
HIGASHIYAMA KENICHI (JP)
Application Number:
PCT/JP2005/016244
Publication Date:
March 16, 2006
Filing Date:
September 05, 2005
Export Citation:
Assignee:
SUNTORY LTD (JP)
HIGASHIYAMA KENICHI (JP)
HIGASHIYAMA KENICHI (JP)
International Classes:
C12N1/14; C12P7/64
Domestic Patent References:
| WO1998039468A1 | 1998-09-11 |
Foreign References:
| JPS4971184A | 1974-07-10 | |||
| JPH1118758A | 1999-01-26 | |||
| JPH1070992A | 1998-03-17 | |||
| JPH06153970A | 1994-06-03 | |||
| JPH02238886A | 1990-09-21 | |||
| JPH0591887A | 1993-04-16 | |||
| JPH0591888A | 1993-04-16 |
Other References:
TSUJIMURA H. AND MATSUMOTO S.: "Ryudo Kaiseki o Kanyo shita Shij kin Baiyo no Scale up. (Scale-up of mycelial fermentation based on analysis of fluid velocity distribution)", BIOSCIENCE & INDUSTRY, vol. 52, no. 10, 1994, pages 805 - 807, XP002998822
SATOSHI MURAKAMI ET AL., KAGAKU KOGAKU RONBUNSHU, vol. 26, no. 4, 2000, pages 557 - 562
A. E. HUMPHERY, HAKKO KOGAKU KAISHI, vol. 42, 1964, pages 334 - 345
C. M. COOPER ET AL., IND. CHEM. ENG., vol. 36, 1944, pages 504 - 509
See also references of EP 1795586A4
SATOSHI MURAKAMI ET AL., KAGAKU KOGAKU RONBUNSHU, vol. 26, no. 4, 2000, pages 557 - 562
A. E. HUMPHERY, HAKKO KOGAKU KAISHI, vol. 42, 1964, pages 334 - 345
C. M. COOPER ET AL., IND. CHEM. ENG., vol. 36, 1944, pages 504 - 509
See also references of EP 1795586A4
Attorney, Agent or Firm:
Kitamura, Shuichiro (Nakanoshima 2-chome Kita-k, Osaka-shi Osaka 05, JP)
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