Title:
METHOD FOR GENERATING PATHOLOGICAL CONDITION INFORMATION, SYSTEM FOR GENERATING PATHOLOGICAL CONDITION INFORMATION, HE4 SUGAR CHAIN ANALYSIS KIT AND HE4
Document Type and Number:
WIPO Patent Application WO/2020/203478
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing: a method for generating pathological condition information, whereby the acquisition, onset, malignant grade, etc. of cancer such as ovarian caner are easily and non-invasively evaluated and thus the cancer can be diagnosed while reducing burden on both a patient and a doctor; a system for generating pathological condition information; and an HE4 sugar chain analysis kit. The method according to the present invention for generating pathological condition information, said method being for generating information relating to the acquisition or onset of cancer, is characterized by comprising: a first step for acquiring information relating to the amount of HE4 that has any of four kinds of residues, i.e., a β-N-acetylgalactosamine residue, an α2,3-sialic acid residue, an α2,6-sialic acid residue and a mannose residue, contained in a test specimen; and a second step for generating information relating to the acquisition or onset of cancer in the subject, who provides the test specimen, depending on the amount of HE4 that has any of the four kinds of residues as described above.
Inventors:
INUI CHIE (JP)
KANEKO TOMONORI (JP)
KAYA TAKATOSHI (JP)
KANEKO TOMONORI (JP)
KAYA TAKATOSHI (JP)
Application Number:
PCT/JP2020/013080
Publication Date:
October 08, 2020
Filing Date:
March 24, 2020
Export Citation:
Assignee:
KONICA MINOLTA INC (JP)
International Classes:
G01N33/53; C12M1/34; G01N33/533; G01N33/574
Domestic Patent References:
| WO2010090264A1 | 2010-08-12 | |||
| WO2015097863A1 | 2015-07-02 |
Foreign References:
| JP2009195240A | 2009-09-03 | |||
| JP2014507153A | 2014-03-27 | |||
| JP2018520353A | 2018-07-26 | |||
| US20150031561A1 | 2015-01-29 |
Other References:
ZHUANG, H. Y. ET AL.: "Overexpression of Lewis y antigen promotes human epididymis protein 4- mediated invasion and metastasis of ovarian cancer cells", BIOCHIMIE, vol. 105, 2014, pages 91 - 98, XP029053855, DOI: 10.1016/j.biochi.2014.06.022
NARIMATSU, M. K. ET AL., FUCOSYLTRANSFERASE FAMILY, 15 May 2001 (2001-05-15), Retrieved from the Internet [retrieved on 20200612]
ZHUANG, H. Y. ET AL.: "Co-expression of Lewis y antigen with human epididymis protein 4 in ovarian epithelial carcinoma", PLOS ONE, vol. 8, no. 7, 2013, pages e68994, XP055745449
HATAKEYAMA, SHINGO, BASIC KNOWLEDGE OF SUGAR CHAINS, 29 March 2017 (2017-03-29), Retrieved from the Internet [retrieved on 20200615]
COOLING, L. L. W. ET AL.: "Trends in Glycoscience and Glycotechnology", GLYCOSPHINGOLIPIDS, vol. 9, no. 46, 1997, pages 191 - 209
DRAPKIN, R. ET AL.: "Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas", CANCER RESEARCH, vol. 65, no. 6, 15 March 2005 (2005-03-15), pages 2162 - 2169, XP002600809, DOI: 10.1158/0008-5472.CAN-04-3924
HUA, L. ET AL.: "Expression and biochemical characterization of recombinant human epididymis protein 4", PROTEIN EXPRESSION AND PURIFICATION, vol. 102, 2014, pages 52 - 62, XP055745448
INUI, CHIE ET AL.: "Development of Novel Glycoprotein Biomarker for Ovarian Cancer Diagnosis with Surface Plasmon field-enhanced Fluorescence Spectroscopy (SPFS", KONICA MINOLTA TECHNOLOGY REPORT, vol. 17, January 2020 (2020-01-01), pages 76 - 80, XP029053855
NARIMATSU, M. K. ET AL., FUCOSYLTRANSFERASE FAMILY, 15 May 2001 (2001-05-15), Retrieved from the Internet
ZHUANG, H. Y. ET AL.: "Co-expression of Lewis y antigen with human epididymis protein 4 in ovarian epithelial carcinoma", PLOS ONE, vol. 8, no. 7, 2013, pages e68994, XP055745449
HATAKEYAMA, SHINGO, BASIC KNOWLEDGE OF SUGAR CHAINS, 29 March 2017 (2017-03-29), Retrieved from the Internet
COOLING, L. L. W. ET AL.: "Trends in Glycoscience and Glycotechnology", GLYCOSPHINGOLIPIDS, vol. 9, no. 46, 1997, pages 191 - 209
DRAPKIN, R. ET AL.: "Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas", CANCER RESEARCH, vol. 65, no. 6, 15 March 2005 (2005-03-15), pages 2162 - 2169, XP002600809, DOI: 10.1158/0008-5472.CAN-04-3924
HUA, L. ET AL.: "Expression and biochemical characterization of recombinant human epididymis protein 4", PROTEIN EXPRESSION AND PURIFICATION, vol. 102, 2014, pages 52 - 62, XP055745448
INUI, CHIE ET AL.: "Development of Novel Glycoprotein Biomarker for Ovarian Cancer Diagnosis with Surface Plasmon field-enhanced Fluorescence Spectroscopy (SPFS", KONICA MINOLTA TECHNOLOGY REPORT, vol. 17, January 2020 (2020-01-01), pages 76 - 80, XP029053855
Attorney, Agent or Firm:
KOYO INTERNATIONAL PATENT FIRM (JP)
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