Title:
METHOD FOR IMPROVING CALCIFICATION OF ARTIFICIAL BIOVALVE BY WAY OF COATING
Document Type and Number:
WIPO Patent Application WO/2020/207021
Kind Code:
A1
Abstract:
Disclosed is a method for improving the calcification of an artificial biovalve by way of a coating. The method comprising first placing a pretreated biovalve material into an aldehyde-containing solution for a chemical cross-linking reaction, wherein the concentration of a solute having an aldehyde group in the aldehyde-containing solution is 0.1%-2% (w/w), and the reaction time is 0.5 hours to 2 weeks; then soaking the biovalve material in an amino silicone oil emulsion, wherein the amino silicone oil emulsion has an amino value range between 0.2-0.6 mmol/g and a viscosity between 500-5000 mPa.s, the soaking time is 0.2 hours to 1 week, and the temperature does not exceed 60ºC. In the method, by introducing a smooth and soft organic material coating into a biovalve leaflet material, the softness and surface smoothness of the valve leaflet are increased, friction is reduced and the risk of calcification is reduced, thereby extending the service life.
Inventors:
CAO PENG (CN)
WANG NA (CN)
GUO GAI (CN)
ZHOU YIYI (CN)
LI YIBIN (CN)
WANG NA (CN)
GUO GAI (CN)
ZHOU YIYI (CN)
LI YIBIN (CN)
Application Number:
PCT/CN2019/120460
Publication Date:
October 15, 2020
Filing Date:
November 25, 2019
Export Citation:
Assignee:
NINGBO JENSCARE BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61F2/24; A61L27/36
Domestic Patent References:
| WO2008154534A2 | 2008-12-18 |
Foreign References:
| CN105363071A | 2016-03-02 | |||
| CN107007887A | 2017-08-04 | |||
| CN101128225A | 2008-02-20 | |||
| CN109589452A | 2019-04-09 | |||
| CN101337088A | 2009-01-07 |
Other References:
LEE ET AL.: "Improved calcification resistance and biocompatibility of tissue patch grafted with sulfonated PEO or heparin after glutaraldehyde fixation", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH (APPL BIOMATER), 31 December 2001 (2001-12-31), XP055741531, DOI: 20200223171123Y
Attorney, Agent or Firm:
ADVANCE CHINA IP LAW OFFICE (CN)
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