Title:
METHOD FOR IMPROVING PHYSICAL PROPERTIES OF ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2012/093704
Kind Code:
A1
Abstract:
The present inventors have discovered that by reducing the binding activity of a polypeptide to an extracellular matrix, it is possible to improve the physical properties of the polypeptide.
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Inventors:
IGAWA TOMOYUKI (JP)
NISHIDA YUKIKO (JP)
NISHIDA YUKIKO (JP)
Application Number:
PCT/JP2012/050129
Publication Date:
July 12, 2012
Filing Date:
January 06, 2012
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
IGAWA TOMOYUKI (JP)
NISHIDA YUKIKO (JP)
IGAWA TOMOYUKI (JP)
NISHIDA YUKIKO (JP)
International Classes:
C07K16/00; C12P21/02; C12P21/08; C12Q1/02; G01N33/53; A61K39/395; A61P37/06
Domestic Patent References:
| WO2009128931A1 | 2009-10-22 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO2004058821A2 | 2004-07-15 | |||
| WO2003002609A2 | 2003-01-09 | |||
| WO2005037989A2 | 2005-04-28 | |||
| WO2002020565A2 | 2002-03-14 | |||
| WO1995001937A1 | 1995-01-19 | |||
| WO2004044011A2 | 2004-05-27 | |||
| WO2005040229A2 | 2005-05-06 | |||
| WO2002032925A2 | 2002-04-25 | |||
| WO2005035756A1 | 2005-04-21 | |||
| WO2006109592A1 | 2006-10-19 |
Foreign References:
| JP2003501089A | 2003-01-14 | |||
| JPH11507726A | 1999-07-06 | |||
| JP2000028609A | 2000-01-28 | |||
| EP0125023A1 | 1984-11-14 |
Other References:
PROC. NATL. ACAD. SCI., vol. 99, no. 17, 2002, pages 11393 - 11398
KABAT ET AL.: "Sequence of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877
NAT BIOTECHNOL., vol. 23, no. 9, September 2005 (2005-09-01), pages 1126 - 36
CURRENT OPINION IN BIOTECHNOLOGY, vol. 17, 2006, pages 653 - 658
CURRENT OPINION IN BIOTECHNOLOGY, vol. 18, 2007, pages 1 - 10
CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 7, 1997, pages 463 - 469
PROTEIN SCIENCE, vol. 15, 2006, pages 14 - 27
BAKER MP; CARR FJ, CURR DRUG SAF., vol. 5, no. 4, 2010, pages 308 - 13
GUIOTTO ET AL., BIOORG. MED. CHEM., vol. 12, 2004, pages 5031 - 5037
KUNKEL, PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
MOL CELL BIOL., vol. 8, 1988, pages 466 - 472
"Current protocols in Molecular Biology", 1987, JOHN WILEY & SONS
VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
EBERT ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
MA ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 131 - 138
COX KM ET AL., NAT. BIOTECHNOL., vol. 24, no. 12, December 2006 (2006-12-01), pages 1591 - 1597
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
GUIOTTO, A. ET AL., BIOORG. MED. CHEM., vol. 12, 2004, pages 5031 - 5037
See also references of EP 2662385A4
KABAT ET AL.: "Sequence of Proteins of Immunological Interest", 1987, NATIONAL INSTITUTE OF HEALTH
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 877
NAT BIOTECHNOL., vol. 23, no. 9, September 2005 (2005-09-01), pages 1126 - 36
CURRENT OPINION IN BIOTECHNOLOGY, vol. 17, 2006, pages 653 - 658
CURRENT OPINION IN BIOTECHNOLOGY, vol. 18, 2007, pages 1 - 10
CURRENT OPINION IN STRUCTURAL BIOLOGY, vol. 7, 1997, pages 463 - 469
PROTEIN SCIENCE, vol. 15, 2006, pages 14 - 27
BAKER MP; CARR FJ, CURR DRUG SAF., vol. 5, no. 4, 2010, pages 308 - 13
GUIOTTO ET AL., BIOORG. MED. CHEM., vol. 12, 2004, pages 5031 - 5037
KUNKEL, PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
MOL CELL BIOL., vol. 8, 1988, pages 466 - 472
"Current protocols in Molecular Biology", 1987, JOHN WILEY & SONS
VICKI GLASER, SPECTRUM BIOTECHNOLOGY APPLICATIONS, 1993
EBERT ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
MA ET AL., EUR. J. IMMUNOL., vol. 24, 1994, pages 131 - 138
COX KM ET AL., NAT. BIOTECHNOL., vol. 24, no. 12, December 2006 (2006-12-01), pages 1591 - 1597
"Strategies for Protein Purification and Characterization: A Laboratory Course Manual", 1996, COLD SPRING HARBOR LABORATORY PRESS
GUIOTTO, A. ET AL., BIOORG. MED. CHEM., vol. 12, 2004, pages 5031 - 5037
See also references of EP 2662385A4
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (JP)
Spring water Original aim (JP)
Spring water Original aim (JP)
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