Title:
METHOD FOR INSPECTING RISK OF CARCINOGENESIS
Document Type and Number:
WIPO Patent Application WO/2014/126044
Kind Code:
A1
Abstract:
Provided are a method with which the risk of cancer and/or carcinogenesis can be detected, and a reagent for detecting the same. Also provided are a method for screening pharmaceutical products that are for reducing the risk of carcinogenesis, and a pharmaceutical composition. The onset of cancer is closely related to changes in the intestinal bacterial flora. So, the occurrence of cancer and/or the risk of occurrence of cancer are/is detected by detecting secondary bile acids produced by enterobacteria and changes in the intestinal bacterial flora. Also provided are a pharmaceutical product screening method that employs the intestinal bacterial flora as an index, and a pharmaceutical composition.
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Inventors:
HARA EIJI (JP)
OTANI NAOKO (JP)
YOSHIMOTO MAKOTO (JP)
LOO TZE MUN (JP)
OTANI NAOKO (JP)
YOSHIMOTO MAKOTO (JP)
LOO TZE MUN (JP)
Application Number:
PCT/JP2014/053048
Publication Date:
August 21, 2014
Filing Date:
February 10, 2014
Export Citation:
Assignee:
JAPAN FOUND CANCER (JP)
International Classes:
C12Q1/02; A61K31/4164; A61K31/43; A61K31/496; A61K31/7036; A61K38/00; A61K45/00; A61P35/00; A61P43/00; G01N33/15; G01N33/50
Domestic Patent References:
| WO2007077893A1 | 2007-07-12 |
Foreign References:
| JP2011184311A | 2011-09-22 | |||
| JP2006056839A | 2006-03-02 | |||
| JP2001253829A | 2001-09-18 |
Other References:
DAIKATSUJI, THE ENCYCLOPEDIA OF MEDICINE, 12 June 2003 (2003-06-12), pages 449
DAPITO ET AL.: "Promotion of Hepatocellular Carcinoma by the Intestinal Microbaiota and TLR4", CANCER CELL, vol. 21, 2012, pages 504 - 516
YOSHIMOTO ET AL.: "Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome", NATURE, vol. 499, 4 July 2013 (2013-07-04), pages 97 - 101
DAPITO ET AL.: "Promotion of Hepatocellular Carcinoma by the Intestinal Microbaiota and TLR4", CANCER CELL, vol. 21, 2012, pages 504 - 516
YOSHIMOTO ET AL.: "Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome", NATURE, vol. 499, 4 July 2013 (2013-07-04), pages 97 - 101
Attorney, Agent or Firm:
SATO & ASSOCIATES (JP)
Patent business corporation creation international patent firm (JP)
Patent business corporation creation international patent firm (JP)
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