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Title:
METHOD OF INTERFERING WITH REPETITIVE RNA
Document Type and Number:
WIPO Patent Application WO/2023/150784
Kind Code:
A3
Abstract:
Provided herein are nuclear expressed antisense RNAs for interfering with a target repetitive RNA, the nuclear expressed antisense RNA comprising: (a) an oligonucleotide encoding an RNA-targeting guide comprising a sequence complementary to the target repetitive RNA; and (b) an oligonucleotide encoding a RNA binding protein (RBP) / ribonucleoprotein (RNP)-recruiting motif.

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Inventors:
YEO EUGENE (US)
SMARGON AARON (US)
HATCH SAMUEL (US)
Application Number:
PCT/US2023/062111
Publication Date:
August 31, 2023
Filing Date:
February 07, 2023
Export Citation:
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Assignee:
UNIV CALIFORNIA (US)
International Classes:
C12N15/113; A61K48/00; A61P21/00; C12N15/864
Domestic Patent References:
WO2020051555A12020-03-12
WO2021020550A12021-02-04
Foreign References:
US20220127611A12022-04-28
Other References:
QUINONES-VALDEZ GIOVANNI, TRAN STEPHEN S., JUN HYUN-IK, BAHN JAE HOON, YANG EI-WEN, ZHAN LIJUN, BRÜMMER ANNEKE, WEI XINTAO, VAN NO: "Regulation of RNA editing by RNA-binding proteins in human cells", COMMUNICATIONS BIOLOGY, vol. 2, no. 1, XP093087710, DOI: 10.1038/s42003-018-0271-8
Attorney, Agent or Firm:
YOON, Sohee Kim et al. (US)
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