METHOD OF INTRODUCING GENE IN TARGET CELL

Title:

METHOD OF INTRODUCING GENE IN TARGET CELL

Document Type and Number:

WIPO Patent Application WO/2005/095623

Kind Code:

A1

Abstract:

There is provided a method characterized by including the steps of: (1) effecting binding of a ligand to be received by a cell surface receptor of target cell to a surface protein of vector; and (2) performing cell infection with the resultant vector under at least one condition selected from among low temperature, low oxygen and short time.

Inventors:

HAYASHI SHUJI (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)

Application Number:

PCT/JP2005/006182

Publication Date:

October 13, 2005

Filing Date:

March 30, 2005

Export Citation:

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Assignee:

DNAVEC RESEARCH INC (JP)
HAYASHI SHUJI (JP)
INOUE MAKOTO (JP)
HASEGAWA MAMORU (JP)

International Classes:

C12N15/86; C12N15/87; C12N5/10; (IPC1-7): C12N15/87

Domestic Patent References:

WO2003004661A2	2003-01-16
WO2002096939A2	2002-12-05

Foreign References:

JPH11501219A

1999-02-02

Other References:

OMORI N. ET AL: "Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to the mouse microglial cell line", NEUROSCIENCE LETTERS, vol. 324, 2002, pages 145 - 148, XP002990103
KHURANA V.G. ET AL: "A direct mechanical method for accurate and efficient adenoviral vector delivery to tissues", GENE THERAPY, vol. 10, 2003, pages 443 - 452, XP002990104
SHAKED A. ET AL: "Adenovirus-mediated gene transfer in the transplant setting", TRANSPLANTATION, vol. 57, no. 10, 1994, pages 1508 - 1511, XP002990105

Attorney, Agent or Firm:

Shimizu, Hatsushi (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)

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