Title:
METHOD FOR MEASURING ANTI-WT1 ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2013/039166
Kind Code:
A1
Abstract:
Provided is an invention relating to a method for measuring anti-WT1 antibodies in a sample according to which the anti-WT1 antibodies can be measured and evaluated more accurately; and to use of the method. A method for measuring anti-WT1 antibodies in a sample, characterized in using: a polypeptide having antigen properties against anti-WT1 antibodies, selected from a polypeptide comprising an amino acid sequence of positions 294-449 in SEQ ID NO: 1, a partial polypeptide of said polypeptide, and a polypeptide comprising an amino acid sequence in which one or several amino acids are removed, replaced, or added with respect to the amino acid sequence constituting the above polypeptides; and/or a polypeptide having antigen properties against anti-WT1 antibodies, selected from a polypeptide comprising an amino acid sequence of positions 181-324 in SEQ ID NO: 1, a partial polypeptide of said polypeptide, and a polypeptide comprising an amino acid sequence in which one or several amino acids are removed, replaced, or added with respect to the amino acid sequence constituting the above polypeptides.
Inventors:
SUGIYAMA HARUO (JP)
OJI YUSUKE (JP)
KATSURAGI KIYONORI (JP)
TANAKA HIDEAKI (JP)
SOGO SHINJI (JP)
GOTO YOSHIHIRO (JP)
OHMOTO YASUKAZU (JP)
IWATA HUSAKO (JP)
OJI YUSUKE (JP)
KATSURAGI KIYONORI (JP)
TANAKA HIDEAKI (JP)
SOGO SHINJI (JP)
GOTO YOSHIHIRO (JP)
OHMOTO YASUKAZU (JP)
IWATA HUSAKO (JP)
Application Number:
PCT/JP2012/073512
Publication Date:
March 21, 2013
Filing Date:
September 13, 2012
Export Citation:
Assignee:
UNIV OSAKA (JP)
OTSUKA PHARMA CO LTD (JP)
SUGIYAMA HARUO (JP)
OJI YUSUKE (JP)
KATSURAGI KIYONORI (JP)
TANAKA HIDEAKI (JP)
SOGO SHINJI (JP)
GOTO YOSHIHIRO (JP)
OHMOTO YASUKAZU (JP)
IWATA HUSAKO (JP)
OTSUKA PHARMA CO LTD (JP)
SUGIYAMA HARUO (JP)
OJI YUSUKE (JP)
KATSURAGI KIYONORI (JP)
TANAKA HIDEAKI (JP)
SOGO SHINJI (JP)
GOTO YOSHIHIRO (JP)
OHMOTO YASUKAZU (JP)
IWATA HUSAKO (JP)
International Classes:
G01N33/53; C07K14/82; C12N15/09; A61K39/00; G01N33/574
Foreign References:
| JP2002048793A | 2002-02-15 | |||
| JP2002048793A | 2002-02-15 | |||
| JP2006267124A | 2006-10-05 |
Other References:
RYO ICHINOHASAMA: "Sensitive immunohistochemical detection of WT1 protein in tumors with anti- WT1 antibody against WT1 235 peptide", CANCER SCI., vol. 101, no. 5, May 2010 (2010-05-01), pages 1089 - 1092, XP055141944
YOSHIHIRO OKA ET AL.: "WT1 Idenshi Sanbutsu o Hyoteki to shita Gan Men'eki Ryoho no Kaihatsu", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 48, no. 11, 2003, pages 1663 - 1670, XP008048427
INOUE K; SUGIYAMA H; OGAWA H ET AL.: "WT1 as a new prognostic factor and new marker for the detection of minimal residual disease in acute leukemia", BLOOD, vol. 84, 1994, pages 3071 - 9, XP002381378
OJI Y; MIYOSHI S; MAEDA H ET AL.: "Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers", INT J CANCER, vol. 100, 2002, pages 297 - 303
MIYOSHI Y; ANDO A; EGAWA C ET AL.: "High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients", CLIN CANCER RES, vol. 8, 2002, pages 1167 - 71, XP002373767
HABER DA; SOHN RL; BUCKLER AJ ET AL.: "Alternative splicing and genomic structure of the Wilms' tumor gene WT1", PROC NATL ACAD SCI USA, vol. 88, 1991, pages 9618, XP002918362, DOI: doi:10.1073/pnas.88.21.9618
MADDEN SL; COOK DM; MORRIS JF ET AL.: "Transcriptional repression mediated by the WTI Wilms tumor gene product", SCIENCE, vol. 253, 1991, pages 1550
OLGA AE1; OKA Y; TSUBOI A ET AL.: "Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies", BLOOD, vol. 99, 2002, pages 3272 - 3279
OJI Y; KITAMURA Y; KAMINO K ET AL.: "WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor", INT J CANCER, vol. 125, 2009, pages 381 - 7, XP055177136, DOI: doi:10.1002/ijc.24367
TAMURA H; DAN K; YOKOSE N ET AL.: "Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes", LEUKEMIA RES, vol. 34, 2010, pages 986 - 990, XP027080522, DOI: doi:10.1016/j.leukres.2009.11.029
BUNSHI IDENGAKU JIKKEN-HO: "Molecular Genetics Experimental Method", 1993, KYORITSU SHUPPAN CO., LTD.
"PCR Technology", 1990, TAKARA SHUZO CO., LTD.
SCIENCE, vol. 224, 1984, pages 1431
BIOCHEM. BIOPHYS. RES. COMM., vol. 130, 1985, pages 692
PROC. NATL. ACAD. SCI. USA., vol. 80, 1983, pages 5990
T. MANIATIS ET AL.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY
"Biochemistry Data Book II", 23 June 1980, TOKYO KAGAKU DOJ IN, CO., LTD., pages: 1175 - 1259
RINSHO KENSA-HO TEIYO: "Clinical Examination Handbook", 1995, KANEHARA & CO., LTD.
TATSUO IWASAKI ET AL.: "Monoclonal antibody", 1984, KODANSYA SCIENTIFIC
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1982, IGAKU SHOIN
See also references of EP 2757373A4
YOSHIHIRO OKA ET AL.: "WT1 Idenshi Sanbutsu o Hyoteki to shita Gan Men'eki Ryoho no Kaihatsu", PROTEIN, NUCLEIC ACID AND ENZYME, vol. 48, no. 11, 2003, pages 1663 - 1670, XP008048427
INOUE K; SUGIYAMA H; OGAWA H ET AL.: "WT1 as a new prognostic factor and new marker for the detection of minimal residual disease in acute leukemia", BLOOD, vol. 84, 1994, pages 3071 - 9, XP002381378
OJI Y; MIYOSHI S; MAEDA H ET AL.: "Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers", INT J CANCER, vol. 100, 2002, pages 297 - 303
MIYOSHI Y; ANDO A; EGAWA C ET AL.: "High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients", CLIN CANCER RES, vol. 8, 2002, pages 1167 - 71, XP002373767
HABER DA; SOHN RL; BUCKLER AJ ET AL.: "Alternative splicing and genomic structure of the Wilms' tumor gene WT1", PROC NATL ACAD SCI USA, vol. 88, 1991, pages 9618, XP002918362, DOI: doi:10.1073/pnas.88.21.9618
MADDEN SL; COOK DM; MORRIS JF ET AL.: "Transcriptional repression mediated by the WTI Wilms tumor gene product", SCIENCE, vol. 253, 1991, pages 1550
OLGA AE1; OKA Y; TSUBOI A ET AL.: "Humoral immune responses against Wilms tumor gene WT1 product in patients with hematopoietic malignancies", BLOOD, vol. 99, 2002, pages 3272 - 3279
OJI Y; KITAMURA Y; KAMINO K ET AL.: "WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor", INT J CANCER, vol. 125, 2009, pages 381 - 7, XP055177136, DOI: doi:10.1002/ijc.24367
TAMURA H; DAN K; YOKOSE N ET AL.: "Prognostic significance of WT1 mRNA and anti-WT1 antibody levels in peripheral blood in patients with myelodysplastic syndromes", LEUKEMIA RES, vol. 34, 2010, pages 986 - 990, XP027080522, DOI: doi:10.1016/j.leukres.2009.11.029
BUNSHI IDENGAKU JIKKEN-HO: "Molecular Genetics Experimental Method", 1993, KYORITSU SHUPPAN CO., LTD.
"PCR Technology", 1990, TAKARA SHUZO CO., LTD.
SCIENCE, vol. 224, 1984, pages 1431
BIOCHEM. BIOPHYS. RES. COMM., vol. 130, 1985, pages 692
PROC. NATL. ACAD. SCI. USA., vol. 80, 1983, pages 5990
T. MANIATIS ET AL.: "Molecular Cloning", 1982, COLD SPRING HARBOR LABORATORY
"Biochemistry Data Book II", 23 June 1980, TOKYO KAGAKU DOJ IN, CO., LTD., pages: 1175 - 1259
RINSHO KENSA-HO TEIYO: "Clinical Examination Handbook", 1995, KANEHARA & CO., LTD.
TATSUO IWASAKI ET AL.: "Monoclonal antibody", 1984, KODANSYA SCIENTIFIC
EIJI ISHIKAWA ET AL.: "Enzyme Immunoassay", 1982, IGAKU SHOIN
See also references of EP 2757373A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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