Title:
METHOD AND MEDICAMENT FOR TREATING AIRWAY AND/OR LUNG DISEASES
Document Type and Number:
WIPO Patent Application WO/2017/077715
Kind Code:
A1
Abstract:
The present invention relates to a method and a medicament for airway and/or lung diseases such as moderate and/or severe asthma disease, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and systemic sclerosis. The medicament contains an agent which inhibits TL1A-DR3 interaction, and the method involves administering an effective amount of the agent to a subject to inhibit at least one symptom, feature or condition selected from hyperplasia of epithelial cells, epithelial metaplasia, hypertrophy of smooth muscle cells, and hyperproliferation of smooth muscle cells, production of extracellular matrix, and/or airway and/or lung tissue remodeling.
Inventors:
CROFT MICHAEL (US)
HERRO RANA (US)
MILLS DAVID (US)
NUGENT RACHEL SOLOFF (US)
LEUNG MONICA (US)
HERRO RANA (US)
MILLS DAVID (US)
NUGENT RACHEL SOLOFF (US)
LEUNG MONICA (US)
Application Number:
PCT/JP2016/004806
Publication Date:
May 11, 2017
Filing Date:
November 02, 2016
Export Citation:
Assignee:
LA JOLLA INST FOR ALLERGY & IMMUNOLOGY (US)
KYOWA HAKKO KIRIN CO LTD (JP)
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
A61K45/00; A61K38/00; A61K39/395; A61P11/00; A61P11/04; A61P11/06
Domestic Patent References:
| WO2015152430A1 | 2015-10-08 | |||
| WO2012161856A1 | 2012-11-29 | |||
| WO2012064682A1 | 2012-05-18 | |||
| WO2013044298A1 | 2013-04-04 | |||
| WO2014106602A1 | 2014-07-10 | |||
| WO2009064854A2 | 2009-05-22 | |||
| WO2007027751A2 | 2007-03-08 | |||
| WO2011017303A1 | 2011-02-10 |
Foreign References:
| US20080003221A1 | 2008-01-03 |
Other References:
HUBEAU, C. ET AL.: "Modulation of IL -17A and TL1A largely abrogates house dust mite-induced lung inflammation in murine model of allergic airway disease", JOURNAL OF INFLAMMATION, vol. 10, no. Suppl. 1, 2013, pages 3, XP021160024
FACCO,M. ET AL.: "TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis", CLINICAL AND MOLECULAR ALLERGY, vol. 13, no. 16, June 2015 (2015-06-01), pages 1 - 11, XP021226474
AIZAWA, H.: "Mechanisms and control of airway remodeling", NIHON KOKYUKI GAKKAI ZASSHI, vol. 41, no. 9, 2003, pages 611 - 619
TSAI, M.: "Therapeutic effects of tumor necrosis factor receptor superfamily 25 (TNFRSF25)- mediated expansion of T-regulatory cells in allergic lung inflammation and airway remodeling", UNIVERSITY OF MIAMI SCHOLARLY REPOSITORY, 2012, OPEN ACCESS DISSERTATIONS
FACCO,M. ET AL.: "TL1A/DR3 axis involvement in the inflammatory cytokine network during pulmonary sarcoidosis", CLINICAL AND MOLECULAR ALLERGY, vol. 13, no. 16, June 2015 (2015-06-01), pages 1 - 11, XP021226474
AIZAWA, H.: "Mechanisms and control of airway remodeling", NIHON KOKYUKI GAKKAI ZASSHI, vol. 41, no. 9, 2003, pages 611 - 619
TSAI, M.: "Therapeutic effects of tumor necrosis factor receptor superfamily 25 (TNFRSF25)- mediated expansion of T-regulatory cells in allergic lung inflammation and airway remodeling", UNIVERSITY OF MIAMI SCHOLARLY REPOSITORY, 2012, OPEN ACCESS DISSERTATIONS
Attorney, Agent or Firm:
EIKOH PATENT FIRM, P.C. (JP)
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