Title:
METHOD FOR PREDICTING EFFECT OF COMBINATION THERAPY ON CANCER USING L-ASPARAGINASE AGENT AND AUTOPHAGY INHIBITOR, AND CANCER THERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2017/110830
Kind Code:
A1
Abstract:
The present invention addresses the problem of finding an index of whether or not a combination therapy using L-asparaginase and an autophagy inhibitor is effective, and providing a cancer therapeutic agent for which the index can be used, and provides: a method for obtaining data on prediction of the effect of a pharmaceutical agent, wherein, when the functional deletion of p53 due to gene mutation is identified in a cancer specimen, the data is determined to be negative in terms of the effect of a combination therapy using L-asparaginase and an autophagy inhibitor on cancer; and a therapeutic agent which is for a cancer showing resistance to sole administration of an L-asparaginase agent, and which is characterized by containing L-asparaginase and an autophagy inhibitor.
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Inventors:
TAKAHASHI HIROYOSHI (JP)
INOUE JUN (JP)
INAZAWA JOHJI (JP)
INOUE JUN (JP)
INAZAWA JOHJI (JP)
Application Number:
PCT/JP2016/087989
Publication Date:
June 29, 2017
Filing Date:
December 20, 2016
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MEDICAL & DENTAL UNIV (JP)
International Classes:
C12Q1/68; A61K31/351; A61K31/47; A61K31/52; A61K31/5377; A61K38/43; A61K45/00; A61P15/00; A61P35/00; A61P35/02; A61P43/00; C12N15/00
Domestic Patent References:
| WO2013051606A1 | 2013-04-11 |
Other References:
SONG, PING ET AL.: "Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells", ONCOTARGET, vol. 6, no. 6, 8 January 2015 (2015-01-08), pages 3861 - 3873, XP055395810
HIROYOSHI TAKAHASHI ET AL.: "Kyusei Lymph-sei Hakketsubyo Saibo ni Oite Autophagy Sogai wa L-asparaginase ni yoru Apoptosis o Zokyo suru", THE 60TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HUMAN GENETICS PROGRAM·SHOROKUSHU, 14 October 2015 (2015-10-14), pages 243, O-83
TAKAHASHI ET AL.: "Autophagy Inhibition Sensitizes Acute Lymphoblastic Leukemia Cells to L-Asparaginase", BLOOD, vol. 126, pages 3772, Retrieved from the Internet [retrieved on 20170317]
HUTSON , RICHARD G. ET AL.: "Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells", AM. J. PHYSIOL., vol. 272, 1997, pages C1691 - C1699, page C1696, XP008175096
EHSANIPOUR , EHSAN A. ET AL.: "Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine", CANCER RES., vol. 73, no. 10, 2013, pages 2998 - 3006, XP055395814
HIROYOSHI TAKAHASHI ET AL.: "Kyusei Lymph-sei Hakketsubyo Saibo ni Oite Autophagy Sogai wa L-asparaginase ni yoru Apoptosis o Zokyo suru", THE 60TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HUMAN GENETICS PROGRAM·SHOROKUSHU, 14 October 2015 (2015-10-14), pages 243, O-83
TAKAHASHI ET AL.: "Autophagy Inhibition Sensitizes Acute Lymphoblastic Leukemia Cells to L-Asparaginase", BLOOD, vol. 126, pages 3772, Retrieved from the Internet
HUTSON , RICHARD G. ET AL.: "Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells", AM. J. PHYSIOL., vol. 272, 1997, pages C1691 - C1699, page C1696, XP008175096
EHSANIPOUR , EHSAN A. ET AL.: "Adipocytes cause leukemia cell resistance to L-asparaginase via release of glutamine", CANCER RES., vol. 73, no. 10, 2013, pages 2998 - 3006, XP055395814
Attorney, Agent or Firm:
SHIMURA Mitsuharu (JP)
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