Title:
METHOD FOR PREDICTING FORMATION OF BLOOD CLOTS OR RISK THEREOF IN MEDICAL DEVICE PERFORMING BLOOD CIRCULATION BY PUMP
Document Type and Number:
WIPO Patent Application WO/2021/182171
Kind Code:
A1
Abstract:
Provided is a means capable of predicting the formation of blood clots or the risk thereof in a medical device which performs blood circulation by a pump, by using a simple and minimally invasive technique. In this method for predicting the formation of blood clots or the risk thereof in a medical device which performs blood circulation by a pump, it is predicted that blood clots are formed or the risk thereof is present in the medical device when the concentration or expression amount of ADAM28 in a body fluid sample collected from a subject attached to the medical device is increasing from a baseline.
Inventors:
HIRAHARA ICHIRO (JP)
FURUKAWA SHINPEI (JP)
KUMANO KOKO (JP)
SATO HIDEKI (JP)
FURUKAWA SHINPEI (JP)
KUMANO KOKO (JP)
SATO HIDEKI (JP)
Application Number:
PCT/JP2021/007826
Publication Date:
September 16, 2021
Filing Date:
March 02, 2021
Export Citation:
Assignee:
TERUMO CORP (JP)
International Classes:
C12Q1/6883; G01N33/53; G01N33/573; G01N33/68
Domestic Patent References:
| WO2016143702A1 | 2016-09-15 | |||
| WO2004035778A1 | 2004-04-29 |
Foreign References:
| JP2017150966A | 2017-08-31 | |||
| JP2012052944A | 2012-03-15 | |||
| JP2016059386A | 2016-04-25 | |||
| US20170246632A1 | 2017-08-31 | |||
| JP2020044275A | 2020-03-26 |
Other References:
MOCHIZUKI, SATSUKI ET AL.: "Effect of ADAM28 on Carcinoma Cell Metastasis by Cleavage of von Willebrand Factor", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 104, no. 12, 2012, pages 906 - 922, XP055255303, DOI: 10.1093/jnci/djs232
MOYNIHAN KJOHNSON KSTRANEY L ET AL.: "Coagulation monitoring correlation with heparin dose in pediatric extracorporeal life support", PERFUSION, vol. 32, no. 8, 2017, pages 675 - 685
FITOUSIS KKLASEK RMASON PEMASUD F: "Evaluation of a pharmacy managed heparin protocol for extracorporeal membrane oxygenation patients", PERFUSION, vol. 32, no. 3, 2017, pages 238 - 244
ESPER SALEVY JHWATERS JH ET AL.: "Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion", ANESTH ANALG, vol. 118, 2014, pages 731 - 743
BROGAN TVTHIAGARAJAN RRRYCUS PT ET AL.: "Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database", INTENSIVE CARE MED, vol. 35, no. 12, 2009, pages 2105 - 2114, XP037119685, DOI: 10.1007/s00134-009-1661-7
SKLAR MCSY ELEQUIER L ET AL.: "Anticoagulation Practices during Venovenous Extracorporeal Membrane Oxygenation for Respiratory Failure. A Systematic Review", ANN AM THORAC SOC, vol. 13, no. 12, 2016, pages 2242 - 2250
SAKATSUME KO ET AL.: "Acquired von Willebrand syndrome caused by high shear stress", ARTIFICIAL ORGANS, vol. 45, no. 3, 2016, pages 225 - 228
RUGGERI ZMZIMMERMAN TS: "Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets", J CLIN INVEST, vol. 65, 1980, pages 1318 - 1325
KALBHENN JSCHMIDT RNAKAMURA L ET AL.: "Early diagnosis of acquired von Willebrand Syndrome (AVWS) is elementary for clinical practice in patients treated with ECMO therapy", J ATHEROSCLER THROMB, vol. 22, no. 3, 2015, pages 265 - 271
DRAPER KVHUANG RJGERSON LB: "GI bleeding in patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis", GASTROINTEST ENDOSC, vol. 80, 2014, pages 435 - 446
SAKATSUME KAKIYAMA MSAITO K ET AL.: "Intractable Bleeding Tendency Due to Acquired Von Willebrand Syndrome After Jarvik 2000 Implant", J ARTIFFICIAL ORGANS, vol. 9, 2016, pages 289 - 292, XP036045506, DOI: 10.1007/s10047-016-0896-7
MASANORI MATSUMOTOYOSHIHIRO FUJIMURA: "Von Willebrand Factor Cleavage Enzyme (ADAMTS13", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 98, no. 7, 2009, pages 1586 - 1592
MOCHIZUKI SSOEJIMA KSHIMODA M ET AL.: "Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor", J NATL CANCER INST, vol. 104, no. 12, 2012, pages 906 - 922, XP055255303, DOI: 10.1093/jnci/djs232
EDWARDS DRHANDSLEY MMPENNINGTON CJ: "The ADAM Metalloproteinases", MOL ASPECTS MED, vol. 29, no. 5, 2008, pages 258 - 289, XP025473840, DOI: 10.1016/j.mam.2008.08.001
MURPHY G: "Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases", SEMIN CELL DEV BIOL, vol. 20, no. 2, 2009, pages 138 - 145, XP026034650, DOI: 10.1016/j.semcdb.2008.09.004
SHIOMI TLEMAITRE VD'ARMIENTO JOKADA Y: "Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases", PATHOL INT., vol. 60, no. 7, 2010, pages 477 - 496
ZHENG X ET AL., J BIOL CHEM., vol. 276, no. 44, 2001, pages 41059 - 63
MOYNIHAN KJOHNSON KSTRANEY L ET AL.: "Coagulation monitoring correlation with heparin dose in pediatric extracorporeal life support", PERFUSION, vol. 32, no. 8, 2017, pages 675 - 685
FITOUSIS KKLASEK RMASON PEMASUD F: "Evaluation of a pharmacy managed heparin protocol for extracorporeal membrane oxygenation patients", PERFUSION, vol. 32, no. 3, 2017, pages 238 - 244
ESPER SALEVY JHWATERS JH ET AL.: "Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion", ANESTH ANALG, vol. 118, 2014, pages 731 - 743
BROGAN TVTHIAGARAJAN RRRYCUS PT ET AL.: "Extracorporeal membrane oxygenation in adults with severe respiratory failure: a multi-center database", INTENSIVE CARE MED, vol. 35, no. 12, 2009, pages 2105 - 2114, XP037119685, DOI: 10.1007/s00134-009-1661-7
SKLAR MCSY ELEQUIER L ET AL.: "Anticoagulation Practices during Venovenous Extracorporeal Membrane Oxygenation for Respiratory Failure. A Systematic Review", ANN AM THORAC SOC, vol. 13, no. 12, 2016, pages 2242 - 2250
SAKATSUME KO ET AL.: "Acquired von Willebrand syndrome caused by high shear stress", ARTIFICIAL ORGANS, vol. 45, no. 3, 2016, pages 225 - 228
RUGGERI ZMZIMMERMAN TS: "Variant von Willebrand's disease: characterization of two subtypes by analysis of multimeric composition of factor VIII/von Willebrand factor in plasma and platelets", J CLIN INVEST, vol. 65, 1980, pages 1318 - 1325
KALBHENN JSCHMIDT RNAKAMURA L ET AL.: "Early diagnosis of acquired von Willebrand Syndrome (AVWS) is elementary for clinical practice in patients treated with ECMO therapy", J ATHEROSCLER THROMB, vol. 22, no. 3, 2015, pages 265 - 271
DRAPER KVHUANG RJGERSON LB: "GI bleeding in patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis", GASTROINTEST ENDOSC, vol. 80, 2014, pages 435 - 446
SAKATSUME KAKIYAMA MSAITO K ET AL.: "Intractable Bleeding Tendency Due to Acquired Von Willebrand Syndrome After Jarvik 2000 Implant", J ARTIFFICIAL ORGANS, vol. 9, 2016, pages 289 - 292, XP036045506, DOI: 10.1007/s10047-016-0896-7
MASANORI MATSUMOTOYOSHIHIRO FUJIMURA: "Von Willebrand Factor Cleavage Enzyme (ADAMTS13", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 98, no. 7, 2009, pages 1586 - 1592
MOCHIZUKI SSOEJIMA KSHIMODA M ET AL.: "Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor", J NATL CANCER INST, vol. 104, no. 12, 2012, pages 906 - 922, XP055255303, DOI: 10.1093/jnci/djs232
EDWARDS DRHANDSLEY MMPENNINGTON CJ: "The ADAM Metalloproteinases", MOL ASPECTS MED, vol. 29, no. 5, 2008, pages 258 - 289, XP025473840, DOI: 10.1016/j.mam.2008.08.001
MURPHY G: "Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases", SEMIN CELL DEV BIOL, vol. 20, no. 2, 2009, pages 138 - 145, XP026034650, DOI: 10.1016/j.semcdb.2008.09.004
SHIOMI TLEMAITRE VD'ARMIENTO JOKADA Y: "Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases", PATHOL INT., vol. 60, no. 7, 2010, pages 477 - 496
ZHENG X ET AL., J BIOL CHEM., vol. 276, no. 44, 2001, pages 41059 - 63
Attorney, Agent or Firm:
HATTA & ASSOCIATES (JP)
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