Title:
METHOD OF PREDICTING PATIENT PROGNOSIS USING RARE CELLS
Document Type and Number:
WIPO Patent Application WO/2017/126634
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for accurately predicting a cancer patient prognosis based on a count of desired cells for which expression of a leukocyte marker and an epithelial marker is hardly exhibited by detecting those cells. Provided is a method for diagnosing an overall survival prognosis for a patient suffering from cancer, the method including: a step of obtaining a concentrated solution containing desired cells by pre-treating a biological sample obtained from the patient; a step of optically detecting the concentrated cells; and a step of detecting the desired cells from the detected image, wherein an association is made with the overall survival prognosis diagnosis by counting the detected desired cells, and wherein the desired cells are cells confirmed by the existence of a cell nucleus and in which expression of a leukocyte marker and an epithelial marker is hardly exhibited.
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Inventors:
AKIYAMA YASUYUKI (JP)
MORIMOTO ATSUSHI (JP)
FUTAMI TORU (JP)
KOIZUMI FUMIAKI (JP)
SAWADA TAKESHI (JP)
MORIMOTO ATSUSHI (JP)
FUTAMI TORU (JP)
KOIZUMI FUMIAKI (JP)
SAWADA TAKESHI (JP)
Application Number:
PCT/JP2017/001817
Publication Date:
July 27, 2017
Filing Date:
January 19, 2017
Export Citation:
Assignee:
TOSOH CORP (JP)
TOKYO METROPOLITAN GOVERNMENT (JP)
TOKYO METROPOLITAN GOVERNMENT (JP)
International Classes:
G01N33/48; C12Q1/02; G01N33/49; G01N33/574
Domestic Patent References:
| WO2015174539A1 | 2015-11-19 | |||
| WO2015046557A1 | 2015-04-02 |
Foreign References:
| JP2011163830A | 2011-08-25 | |||
| JP2015006169A | 2015-01-15 | |||
| JP2013508729A | 2013-03-07 |
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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