METHOD FOR PREPARING 6,7-DIHYDROXYCOUMARIN-3-CARBOXY COMPOUND

WIPO Patent Application WO/2003/076423

A1

A method for preparing 6,7-dihyfroxycoumarin-3- carboxy compound having formula (3), wherein R is H or an alkyl group, being useful as an intermediate of a medicine or the like, which comprises reacting 6,7-methylenedioxycoumarin-3-carboxy compound having formula (1) with molecular chlorine in the presence of a chlorine-containing compound (such as PCl₃ and PCl₅) to form 6,7-chloromethylenedioxycoumarin-3-carboxy compound having formula (2), and subjecting the 6,7-chloromethylenedioxycoumarin-3-carboxy compound to a hydrolysis reaction or alcoholysis reaction.

SHIRAI MASASHI (JP)
FURUYA TOSHIO (JP)

PCT/JP2003/002802

September 18, 2003

March 10, 2003

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UBE INDUSTRIES (JP)
SHIRAI MASASHI (JP)
FURUYA TOSHIO (JP)

C07D493/04; (IPC1-7): C07D311/16; C07D493/14

WO1993016064A1	1993-08-19
WO2002053552A1	2002-07-11

EP0786446A1	1997-07-30
US5716944A	1998-02-10
EP1270550A1	2003-01-02

TANADA YOSHIHISA ET AL.: "Synthesis and absolute configuration of (-)-neuchromenin, a neurotrophic metabolite of eupenicillium javanicum var. meloforme and its enantiomer", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 10, 2001, pages 1963 - 1966, XP002970088
KHAIKIN M.S. ET AL.: "Ultraviolet spectra of some 6,7-and 7,8-dihydroxycoumarins", ZHURNAL PRIKLADNOI SPEKTROSKOPII, vol. 8, no. 6, 1968, pages 1063 - 1066, XP002970089

Ishida, Takashi (ISHIDA & ASSOCIATES Toranomon 37 Mori Bldg. 5-, Toranomon 3-chome Minato-ku Tokyo, JP)

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