Title:
METHOD FOR PREPARING CITRULLINE
Document Type and Number:
WIPO Patent Application WO/2015/111597
Kind Code:
A1
Abstract:
Disclosed are a method for preparing citrulline that makes it possible to produce citrulline efficiently, and a method for producing a citrulline-containing composition containing citrulline at high concentration. Also disclosed are a method for culturing and a method for fermenting microorganisms having increased conversion efficiency from arginine to citrulline, and a culture method that increases the concentration of microorganisms having the ability to produce citrulline. Citrulline can be produced efficiently by inoculating medium with microorganisms having the ability to produce citrulline and culturing at a higher temperature than usual, and by adding microorganisms having the ability to produce citrulline to a raw material and fermenting at a higher temperature than usual. The conversion efficiency from arginine to citrulline can also be increased, or the concentration of microorganisms can be increased, by adding arginine to medium or raw material and culturing or fermenting microorganisms having the ability to produce citrulline, and by culturing by controlling the pH of the medium.
Inventors:
FURUICHI KEISUKE (JP)
WATANABE REIKO (JP)
ITOU HIROYUKI (JP)
YAMAMOTO ERI (JP)
WATANABE REIKO (JP)
ITOU HIROYUKI (JP)
YAMAMOTO ERI (JP)
Application Number:
PCT/JP2015/051462
Publication Date:
July 30, 2015
Filing Date:
January 21, 2015
Export Citation:
Assignee:
MEIJI CO LTD (JP)
International Classes:
C12P13/10; C12N1/00; C12N1/20; C12N15/09
Foreign References:
| JPH04287636A | 1992-10-13 |
Other References:
WANG Y ET AL.: "Study on optimization on fermentation conditions of producing citrulline by Enterococcus faecalis SK 23.001", SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY, vol. 33, 2012, pages 233 - 241
ZHAO Y ET AL.: "Enzymatic and continuous production of L-citrulline by immobilized Streptococcus faecalis cells", JOURNAL OF BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY ( NATURAL SCIENCE, vol. 37, 2010, pages 98 - 102
VRANCKEN G ET AL.: "The arginine deiminase pathway of Lactobacillus fermentum IMDO 130101 responds to growth under stress conditions of both temperature and salt", FOOD MICROBIOLOGY, vol. 26, 2009, pages 720 - 727, XP026583272
POOLMAN B ET AL.: "Regulation of arginine- ornithine exchange and the arginine deiminase pathway in Streptococcus lactis", JOURNAL OF BACTERIOLOGY, vol. 169, 1987, pages 5597 - 5604, XP055214696
HU Y ET AL.: "Study on the Production of L- citrulline by Engineering Bacteria and Applied to the Tobacco", SHIPIN GONGYE, vol. 33, 2012, pages 55 - 58
KUNIO YAMAUCHI ET AL., MILK SOGO JITEN, 1998, pages 233 - 251
ZHAO Y ET AL.: "Enzymatic and continuous production of L-citrulline by immobilized Streptococcus faecalis cells", JOURNAL OF BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY ( NATURAL SCIENCE, vol. 37, 2010, pages 98 - 102
VRANCKEN G ET AL.: "The arginine deiminase pathway of Lactobacillus fermentum IMDO 130101 responds to growth under stress conditions of both temperature and salt", FOOD MICROBIOLOGY, vol. 26, 2009, pages 720 - 727, XP026583272
POOLMAN B ET AL.: "Regulation of arginine- ornithine exchange and the arginine deiminase pathway in Streptococcus lactis", JOURNAL OF BACTERIOLOGY, vol. 169, 1987, pages 5597 - 5604, XP055214696
HU Y ET AL.: "Study on the Production of L- citrulline by Engineering Bacteria and Applied to the Tobacco", SHIPIN GONGYE, vol. 33, 2012, pages 55 - 58
KUNIO YAMAUCHI ET AL., MILK SOGO JITEN, 1998, pages 233 - 251
Attorney, Agent or Firm:
KONNO, Akio et al. (JP)
Akio Konno (JP)
Akio Konno (JP)
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