METHOD FOR PREPARING COMBRETASTATINS

Title:

METHOD FOR PREPARING COMBRETASTATINS

Document Type and Number:

WIPO Patent Application WO2003084919

Kind Code:

A3

Abstract:

The invention concerns novel methods for preparing combretastatins by Wittig condensation between nitromethoxy-benzaldehyde and a trimethoxybenzyl phosphonium salt or inversely a nitromethoxybenzyl phosphonium salt with trimethoxybenzylaldehyde or further by a Wittig reaction on the same derivatives whereof the nitro function has been reduced into an amino group.

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Inventors:

MUTTI STEPHANE
LAVIGNE MICHEL
MALEJONOCK IRINA
CASIMIR JEAN-PAUL

Application Number:

PCT/FR2003/001117

Publication Date:

April 08, 2004

Filing Date:

April 09, 2003

Export Citation:

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Assignee:

AVENTIS PHARMA SA (FR)

International Classes:

C07C213/02; C07C217/84; C07D263/06; C07D263/04; (IPC1-7): C07C213/02; C07D263/06

Foreign References:

US5731353A	1998-03-24
US5674906A	1997-10-07

Other References:

PINNEY K G ET AL: "Synthesis and biological evalution of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 8, no. 10, 2000, pages 2417 - 2425, XP002955631, ISSN: 0968-0896

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