Title:
METHOD FOR PREPARING EXTRACELLULAR MATRIX-INDUCED SELF-ASSEMBLY-BASED 3D PRINTED ARTIFICIAL TISSUE, AND ARTIFICIAL TISSUE PREPARED THEREBY
Document Type and Number:
WIPO Patent Application WO/2023/211147
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing an extracellular matrix-induced self-assembly-based 3D printed artificial tissue, and artificial tissue prepared thereby, and provides: a method in which a self-assembly, formed by inducing stem cell differentiation using extracellular matrix-derived biomaterials, is applied to 3D printing so that artificial tissue can be fine-patterned with widths in units of micrometers and morphological appearance of origin tissue can be implemented; and artificial tissue printed in a mature tissue form, which is not that of a cell-biomaterial mixture from the time of printing. The artificial tissue prepared by the preparation method of the present invention mimics the biological characteristics of a target organ according to the origin of the extracellular matrix, and thus enables artificial tissue and artificial organs very similar to actual original tissue to be provided.
Inventors:
PARK DOYOUNG (KR)
YUN HEEWOONG (KR)
NOH SUJIN (KR)
YUN HEEWOONG (KR)
NOH SUJIN (KR)
Application Number:
PCT/KR2023/005678
Publication Date:
November 02, 2023
Filing Date:
April 26, 2023
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
A61L27/36; A61L27/38; B33Y10/00; C12N5/071; C12N5/0735; C12N5/074; C12N5/0775
Foreign References:
| KR20220038705A | 2022-03-29 | |||
| KR20210037242A | 2021-04-06 |
Other References:
YU YIN, MONCAL KAZIM K., LI JIANQIANG, PENG WEIJIE, RIVERO IRIS, MARTIN JAMES A., OZBOLAT IBRAHIM T.: "Three-dimensional bioprinting using self-assembling scalable scaffold-free “tissue strands” as a new bioink", SCIENTIFIC REPORTS, vol. 6, no. 1, XP093102676, DOI: 10.1038/srep28714
KAROLY JAKAB, CYRILLE NOROTTE, FRANCOISE MARGA, KEITH MURPHY, GORDANA VUNJAK-NOVAKOVIC, GABOR FORGACS: "Tissue engineering by self-assembly and bio-printing of living cells", BIOFABRICATION, INSTITUTE OF PHYSICS PUBLISHING LTD., UK, vol. 2, no. 2, 1 June 2010 (2010-06-01), UK , pages 022001, XP055450043, ISSN: 1758-5082, DOI: 10.1088/1758-5082/2/2/022001
SEVILLA CARLOS A., DALECKI DIANE, HOCKING DENISE C.: "Extracellular Matrix Fibronectin Stimulates the Self-Assembly of Microtissues on Native Collagen Gels", TISSUE ENGINEERING PART A, MARY ANN LIEBERT, US, vol. 16, no. 12, 1 December 2010 (2010-12-01), US , pages 3805 - 3819, XP093102680, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2010.0316
KAROLY JAKAB, CYRILLE NOROTTE, FRANCOISE MARGA, KEITH MURPHY, GORDANA VUNJAK-NOVAKOVIC, GABOR FORGACS: "Tissue engineering by self-assembly and bio-printing of living cells", BIOFABRICATION, INSTITUTE OF PHYSICS PUBLISHING LTD., UK, vol. 2, no. 2, 1 June 2010 (2010-06-01), UK , pages 022001, XP055450043, ISSN: 1758-5082, DOI: 10.1088/1758-5082/2/2/022001
SEVILLA CARLOS A., DALECKI DIANE, HOCKING DENISE C.: "Extracellular Matrix Fibronectin Stimulates the Self-Assembly of Microtissues on Native Collagen Gels", TISSUE ENGINEERING PART A, MARY ANN LIEBERT, US, vol. 16, no. 12, 1 December 2010 (2010-12-01), US , pages 3805 - 3819, XP093102680, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2010.0316
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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