Title:
METHOD FOR PREPARING HUMAN HEPATOCYTE PROGENITOR CELLS
Document Type and Number:
WIPO Patent Application WO/2018/079714
Kind Code:
A1
Abstract:
Provided is a method for reprograming in vitro human mature hepatocytes into hepatocyte precursor cells having the ability to self-renew. A method for preparing human hepatocyte progenitor cells, said method comprising culturing human mature hepatocytes in a medium containing serum, A-83-01 and CHIR99021.
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Inventors:
KATSUDA TAKESHI (JP)
OCHIYA TAKAHIRO (JP)
YAMADA TETSUMASA (JP)
OCHIYA TAKAHIRO (JP)
YAMADA TETSUMASA (JP)
Application Number:
PCT/JP2017/038907
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
NAT CANCER CT (JP)
INTERSTEM CO LTD (JP)
INTERSTEM CO LTD (JP)
International Classes:
C12N5/071; A61P1/16; C12N1/00; C12N7/00; C12Q1/02; A61K35/407
Domestic Patent References:
| WO2013018851A1 | 2013-02-07 | |||
| WO2017119512A1 | 2017-07-13 | |||
| WO2007058308A1 | 2007-05-24 |
Foreign References:
| JP2006254896A | 2006-09-28 | |||
| JP2014501108A | 2014-01-20 | |||
| JP2013507932A | 2013-03-07 |
Other References:
ATSUSHI M. ET AL.: "Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming", CELL STEM CELL, vol. 14, 1 May 2014 (2014-05-01), pages 561 - 574, XP055397279
NINOMIYA, SHINICHI ET AL.: "Effects of hepatotoxicants on hepatic gene expression in chimeric mice with highly humanized liver", THE 41ST ANNUAL MEETING OF THE JAPANESE SOCIETY OF TOXICOLOGY, 26 August 2014 (2014-08-26), pages 97, XP055599306
TAKASHI K. ET AL.: "Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity", CELL STEM CELL, vol. 20, 5 January 2017 (2017-01-05), pages 41 - 55, XP055397277
KATSUTA, TAKESHI ET AL.: "In vitro chemical reprogramming of mature hepatocytes into bipotent liver progenitor cells", REGENERATIVE MEDICINE, vol. 15, 1 February 2016 (2016-02-01), pages 240 , XP009515234
YANGER K., GENES & DEVELOPMENT, vol. 27, 2013, pages 719 - 724
TANIMIZU N., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 11, 2014, pages 7589 - 7598
YIMLAMAI D., CELL, vol. 157, 2014, pages 1324 - 1338
TARLOW B. D., CELL STEM CELL, vol. 15, 2014, pages 605 - 618
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 909910-43-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 252917-06-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 146986-50-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 850664-21-0
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 105628-07-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 871543-07-6
HORN DBSQUIRE CR, CHIM. ACTA., vol. 14, 1966, pages 185 - 194
AKIYAMA I., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 14, 2004, pages 663 - 668
T. TAKEUCHI ET AL.: "Real-Time Detection System for Quantification of Hepatitis C Virus Genome", GASTROENTEROLOGY, vol. 116, 1999, pages 636 - 642
NINOMIYA, SHINICHI ET AL.: "Effects of hepatotoxicants on hepatic gene expression in chimeric mice with highly humanized liver", THE 41ST ANNUAL MEETING OF THE JAPANESE SOCIETY OF TOXICOLOGY, 26 August 2014 (2014-08-26), pages 97, XP055599306
TAKASHI K. ET AL.: "Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity", CELL STEM CELL, vol. 20, 5 January 2017 (2017-01-05), pages 41 - 55, XP055397277
KATSUTA, TAKESHI ET AL.: "In vitro chemical reprogramming of mature hepatocytes into bipotent liver progenitor cells", REGENERATIVE MEDICINE, vol. 15, 1 February 2016 (2016-02-01), pages 240 , XP009515234
YANGER K., GENES & DEVELOPMENT, vol. 27, 2013, pages 719 - 724
TANIMIZU N., JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 289, no. 11, 2014, pages 7589 - 7598
YIMLAMAI D., CELL, vol. 157, 2014, pages 1324 - 1338
TARLOW B. D., CELL STEM CELL, vol. 15, 2014, pages 605 - 618
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 909910-43-6
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 252917-06-9
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 146986-50-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 850664-21-0
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 105628-07-7
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 871543-07-6
HORN DBSQUIRE CR, CHIM. ACTA., vol. 14, 1966, pages 185 - 194
AKIYAMA I., INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, vol. 14, 2004, pages 663 - 668
T. TAKEUCHI ET AL.: "Real-Time Detection System for Quantification of Hepatitis C Virus Genome", GASTROENTEROLOGY, vol. 116, 1999, pages 636 - 642
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
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