Title:
METHOD FOR PREPARING OLIGOMERIC MANNURONIC DIACID
Document Type and Number:
WIPO Patent Application WO/2018/032272
Kind Code:
A1
Abstract:
A novel method for preparing an important bioactive substance, oligomeric mannuronic diacid. The method uses oligomeric mannuronic acid as the starting material and obtains the target substance by means of steps of acid degradation and active hypobromous acid oxidation. The method for preparing the oligomeric mannuronic diacid in the present invention uses mild reaction conditions, has fewer side reactions, does not require further purification, can reach a yield of 90% or more, even 95% or more, and is suitable for production in an on-line continuous reaction device, and an automated control is easily achieved for reaction process thereof.
Inventors:
XIAO ZHONGPING (CN)
ZHANG ZHENQING (CN)
GENG MEIYU (CN)
DING JIAN (CN)
ZHANG ZHENQING (CN)
GENG MEIYU (CN)
DING JIAN (CN)
Application Number:
PCT/CN2016/095368
Publication Date:
February 22, 2018
Filing Date:
August 15, 2016
Export Citation:
Assignee:
SHANGHAI GREEN VALLEY PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H1/00; C07H7/033
Domestic Patent References:
| WO2002032913A1 | 2002-04-25 |
Foreign References:
| CN100508985C | 2009-07-08 | |||
| GB289280A | 1928-04-26 |
Other References:
THABURET, J. -F. ET AL.: "TEMPO-mediated Oxidation of Maltodextrins and D-glucose: Effect of pH on the Selectivity and Sequestering Ability of the Resulting Polycarboxylates", CARBOHYDRATE RESEARCH, vol. 330, 31 December 2001 (2001-12-31), pages 21 - 29, XP001031234, DOI: doi:10.1016/S0008-6215(00)00263-9
See also references of EP 3498722A4
See also references of EP 3498722A4
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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